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US 2003/0211459 A1Published application
Drug development by rapid neuroimaging of neural cells
AssigneeThe General Hospital Corporation
InventorsHans Breiter, David Borsook
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Abstract
The invention provides a method for identifying potential therapeutic agents by relating in vitro techniques for drug screening of neural cells with neural circuitry function in animals and humans. The method involves objectively measuring, in a quantifiable and reproducible manner, the effects of the agents on pain and other motivational functions.
Claims17
A method for identifying an agent that can be used to treat a neurologically-based condition, comprising the steps of:
- (a) obtaining a set of in vitro neural cells;
- (b) obtaining data from contacting the set of in vitro neural cells with an agent suspected of being an agent that can be used to treat the neurologically-based condition;
- (c) obtaining neuroimaging data from neural cells corresponding to the set of in vitro neural cells, wherein the corresponding cells are contacted with the agent suspected of being an agent that can be used to treat the neurologically-based condition;
- and
- (d) correlating the data obtained from contacting the set of in vitro neural cells with the agent with the neuroimaging data, wherein a correlation between the data obtained from contacting the set of in vitro neural cells with the agent and the neuroimaging data identifies the agent as an agent that can be used to treat the neurologically-based condition.
2 more elements
A method for correlating fMRI data, comprising the steps of:
- (a) obtaining a set of in vitro neural cells;
- (b) obtaining fMRI neuroimaging data from the interaction of the set of in vitro neural cells contacted with an agent suspected of being an agent that can be used to treat a neurologically-based condition;
- and
- (c) correlating the fMRI neuroimaging data obtained from the interaction of set of in vitro neural cells contacted with the agent with the fMRI neuroimaging data obtained in vivo, wherein a correlation between the fMRI neuroimaging data obtained from the interaction of set of in vitro neural cells contacted with the agent and the fMRI neuroimaging data obtained in vivo identifies the agent as an agent that can be used to treat the neurologically-based condition.
1 more element
Dependencies are inferred from the claim text.