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US 2003/0211166 A1Published application
Microparticulate biomaterial composition for medical use
OwnerRonald K Yamamoto, Stanley R. Constoninventors
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OwnerRonald K Yamamoto, Stanley R. Constoninventors
Estimating the term…
Compositions of microspheres formed of stabilized hyaluronic acid are disclosed. The unique biological properties of hyaluronic acid provide for very inert properties when exposed to tissues. Microsphere formulations of hyaluronic acid have medical utility due to the resultant properties of flowability, physical stability, and degradability. High concentration formulations of the microspheres have utility when injected to form a localized mass within tissues by providing physical stability and anti-fibrotic biological activity, especially suitable for certain surgical reconstructions. Low concentration formulation of the microspheres of the appropriate size range have utility when injected into the blood system to delivery diagnostic and therapeutic compounds.
An injectable composition for use in direct tissue contact, comprising microspheres of stabilized hyaluronic acid, wherein said microspheres are substantially spherical and uniform such that close packing rules apply to a mass of said microspheres providing an implant with interconnected porosity when injected into tissues.
An injectable composition for use in drug delivery, comprising microspheres of stabilized hyaluronic acid, wherein said microspheres are substantially spherical and less than 7 microns in diameter in a hydrated state in blood, thereby providing a freely circulating collection of microspheres after administration to the blood system, said microspheres also containing a therapeutic or diagnostic agent.
A process for fabrication of hyaluronic acid microspheres wherein a dispersion or colloidal solution of hyaluronic acid is sprayed to physically form microspheres of a desired size.
An injectable microsphere composition for use in drug delivery, comprising microspheres of stabilized hyaluronic acid and a diagnostic or therapeutic agent, wherein said microspheres demonstrate anti-fibrotic activity in direct tissue contact.
Dependencies are inferred from the claim text.