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US 2003/0211162 A1Published application
Process for producing nanometer particles by fluid bed spray-drying
OwnerNicholas J. Kerkhofinventor
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Abstract
Nanometer particles of poorly water-soluble or substantially water-insoluble compound are produced by finely-spraying a non-aqueous solution of said compound into a heated and fluidized bed of carrier excipient. The resulting product consists of a free flowing mixture of relatively large particles of carrier excipient and nanometer sized particles (less than 3 μm)) of compound.
Claims27
A process for producing a mixture of nanometer particles of a poorly water soluble or substantially water-insoluble compound and a carrier excipient, said process comprising,
- spraying a solution of a water-insoluble or poorly water soluble compound in at least one organic solvent into a fluidized bed of carrier excipient particles, under conditions that allow for a substantial amount of organic solvent to be removed from said solution, such that a mixture of carrier excipient and particles of said compound having a volume-weighted mean diameter of less than or equal to 3000 nm is formed.
A method of preparing nanoparticles, comprising the steps of:
- dissolving a compound in a liquid medium comprising at least one organic solvent to form a solution;
- spraying said solution into a fluidized bed of a carrier excipient particles having an average particle size of from about 10 μm to about 3 mm, wherein said carrier excipient particles are selected from the group consisting of xylitol, mannitol, sorbitol, arabinose, ribose, xylose, glucose, mannose, galactose, sucrose and lactose;
- under conditions of airflow temperature and pressure such that compound particles are formed in admixture with the carrier excipient particles, wherein said compound particles have an average particle size less than or equal to 3000 nm.
Dependencies are inferred from the claim text.