Semi-sol delivery blend for water soluble molecules
OwnerDavid Lew Simoninventor
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Abstract
The present invention relates to novel methods and compositions for administration of water-soluble small molecules for the treatment of opioid addiction, alcoholism and HIV infection, especially where the water-soluble small molecules are pentacyclic and structurally similar to nalmefene, buprenorphine, 6-beta-naltrexol and nalbuphine.
Claims15
) A drug delivery system comprising a biodegradable copolymer, a plasticizer, and an effective amount of a water-soluble drug.
) The drug delivery system of claim 1 where the biodegradable copolymer is PLGA.
) The drug delivery system of claim 1 where the plasticizer is triacetin.
) The drug delivery system of claim 1 where the water-soluble drug is an opioid antagonist.
) The drug delivery system of claim 4 where the opioid antagonist is nalmefene.
) A drug delivery system comprising a biodegradable copolymer, a plasticizer, an effective amount of a water-soluble drug, and a steroidal anti-inflammatory drug.
) The drug delivery system of claim 6 where the steroidal anti-inflammatory agent is triamcinolone.
) A method of treating alcoholism comprising administration of nalmefene.
) A method of treating HIV infection comprising administration of an opioid antagonist.
) The method of claim 9 where the opioid antagonist is nalmefene.
) A pharmaceutical composition comprising an opioid agonist analgesic and 6-beta-naltrexol.
) A pharmaceutical composition comprising an opioid agonist analgesic and nalbuphine.
) The drug delivery system of claim 4 where the opioid antagonist is 6-beta-naltrexol.
) The drug delivery system of claim 4 where the opioid antagonist is nalbuphine.
) The drug delivery system of claim 1 where the water-soluble drug is buprenorphine.