Coating composition for facilitating controlled release
OwnerGour Mukherji, Manoj Kumarinventors
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Abstract
The present invention relates to an extended release formulation comprising a coated drug containing core, wherein the coating is an aqueous coating, comprising an aqueous polymer dispersion of a water-insoluble film forming polymer in combination with an aqueous colloidal solution of a high viscosity swellable polymer.
Claims22
An extended release formulation comprising:
- a drug containing core coated with an aqueous coating composition, wherein the coating composition comprises a polymer dispersion of a water insoluble film forming polymer in combination with a high viscosity swellable polymer.
The formulation of claim 7 wherein the polysaccharide is selected from the group consisting of xanthan gum, guar gum, locust bean gum and tragacanth gum.
The formulation of claim 7 wherein the cross-linked polyacrylic acid is carbomer.
The formulation of claim 12, wherein the channeling agents are selected from the group consisting of lactose, starch and talc.
The formulation of claim 12, wherein the channeling agent is present upto 50% or more preferably upto 30% w/w of polymers.
The formulation of claim 15, wherein the lubricants are selected from the group consisting of talc, colloidal silica and magnesium stearate.
The formulation of claim 15, wherein the lubricants are present upto 200% or more preferably upto 100% w/w of the film-forming polymer.
The formulation of claim 18, wherein the plasticizers are selected from the group consisting of acetyl citrate, triacetin, acetylated monoglyceride, rape oil, olive oil, sesame oil, acetyltriethyl citrate, glycerin sorbitol, diethyloxalate, diethylmalate, diethylfumarate, dibutylsuccinate, dibutyl phthalate, diethylmaloate, dioctylphthalate, dibutylsebacate, triethylcitrate, tributylcitrate, glyceroltributyrate, glyceryl triacetate, polyethyleneglycol, propylene glycol, and mixtures thereof.
The formulation of claim 18, wherein the plasticiser is preferably polyethylene glycol (PEG).
The formulation of claim 23, wherein the formulation suitable for oral administration may be conventional whole chewable tablet, dispersible tablet, suspension or dry powder for reconstitution, for sprinkle or any other suitable oral dosage form.
Dependencies are inferred from the claim text.