Ibuprofen containing hard shell capsules
AssigneeWarner-Lambert Company
InventorsEmmanuelle Mireille Guillard, Nicolas Madit, Robert Anthony Scott
Life of this patent
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Abstract
The present invention relates to pharmaceutically acceptable and stable compositions, which are preferably clear transparent, for liquid filling hard shell capsules, hard shell capsules containing these compositions, and a process for preparing these hard shell capsules and whereby the shells of said hard capsules are preferably clear transparent.
Claims10
Pharmaceutically acceptable composition for liquid filling hard shell capsules comprising, based upon the total weight of the composition,
- a) from 35 to 75% by weight ibuprofen,
- b) from 1 to 10% by weight alkali hydroxide, and
- c) from 15 to 55% by weight of an emulsifier selected from polyoxyethylene alkyl ethers, medium chain triglycerides, propylene glycol esters, glyceryl esters, sorbitan esters, polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, castor oil, or mixtures therof,
- wherein the molar ratio between alkali hydroxide b) and ibuprofen a) is from 0.1 to 0.5.
A liquid filled pharmaceutical hard capsule containing a composition which comprises, based upon the total weight of the composition,
- a) from 35 to 75% by weight ibuprofen,
- b) from 1 to 10% by weight alkali hydroxide, and
- c) from 15 to 55% by weight of an emulsifier selected from polyoxyethylene alkyl ethers, medium chain triglycerides, propylene glycol esters, glyceryl esters, sorbitan esters, polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, castor oil, or mixtures therof,
- wherein the molar ratio between alkali hydroxide b)and ibuprofen a) is from 0.1 to 0.5.
Dependencies are inferred from the claim text.