Liposome
AssigneeTerumo Kabushiki Kaisha
InventorsKazuo Kawahara, Hideto Ushijima, Hideki Uchiyama, Junji Kimura, Hiroaki Kasukawa
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Abstract
This invention provides a liposome having a drug included therein, which has active targeting property and ensured stability in blood and can be used effectively in the diagnosis and/or treatment of diseases, particularly renal diseases, that accompany production of proteoglycan, comprising (1) a basic compound which takes positive charge within a physiological pH range, (2) a lipid derivative of a hydrophilic polymer and (3) a lipid which constitutes the liposome, as its membrane constituting components, wherein their constituting ratios are from 1 to 20 mol % of (1) based on (3) and from 0.2 to 5 mol % of (2) based on the total of (1) and (3).
Claims16
A liposome in which a drug is included, which comprises (1) a basic compound which takes positive charge within a physiological pH range, (2) a lipid derivative of a hydrophilic polymer and (3) a lipid which constitutes the liposome, as its membrane constituting components, wherein their constituting ratios are from 1 to 20 mol % of (1) based on (3) and from 0.2 to 5 mol % of (2) based on the total of (1) and (3).
A liposome in which a drug is included, which comprises (1) a basic compound which takes positive charge within a physiological pH range, (2) a lipid derivative of a hydrophilic polymer and (3) a lipid which constitutes the liposome, as its membrane constituting components, wherein their constituting ratios are from 5 to 15 mol % of (1) based on (3) and from 0.2 to 5 mol % of (2) based on the total of (1) and (3).
Dependencies are inferred from the claim text.