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US 2003/0211140 A1Published application
Oil-core compositions for the sustained release of hydrophobic drugs
OwnerSankaram Mantripragada, Richard N. Thriftinventors
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OwnerSankaram Mantripragada, Richard N. Thriftinventors
Estimating the term…
Physiologically active oil-core particles, and a method of making physiologically active oil-core particles that include a hydrophobic core material, a hydrophobic drug dissolved or suspended in the core material, and a layer of amphipathic lipids surrounding the hydrophobic core. An optional continuous phase can be an oil-immiscible solution. In one aspect, the method involves the use of a volatile solvent that is removed after the formation of the suspension. The suspension can be used substantially as created, or the particles formulated as a solid dosage form. In another aspect, the particles are formed substantially simultaneously with the volatilization of a propellant, for example, by spraying through an atomizing actuator. The resulting particles have superior particle size distribution and yield properties. The method is appropriate for use with physiologic agents that would be sensitive to heating during the encapsulating process, and also allows aseptic processing by filtration without heating the solutions used in processing.
Physiologically active oil-core particles, wherein each particle comprises:
A method of making physiologically active oil-core particles, the method comprising:
A method of making physiologically active oil-core particles, the method comprising:
A method of making physiologically active oil-core particles, the method comprising:
The method of claim 38, wherein the drug is paclitaxel.
The method of claim 38, wherein the drug is bupivacaine.
Dependencies are inferred from the claim text.