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OwnerWilliam B Spillman JR., You-Xiong Wang +1inventors
InventorsWilliam B Spillman JR., You-Xiong Wang, Richard O Claus
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We make a substrate biocompatible by contacting it with a starting material and initiating alternating charge layer electrostatic self assembly to form a thin film. Starting materials may be poly(vinylpyrrolidone), poly{bis-(carboxylatophenoxy)phosphazene}, poly(methacrylic acid), poly(l)-lysine, poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene, long-sidechain fullerene, or other polymers that participate in electrostatic self-assembly. The thin film fabrication advantageously may be at room temperature. A biocompatible thin film that is uniform and homogeneous can be provided. Optionally, ZrO2, Al2O3 or TiO2 nanoclusters also may be used in the film assembly. The film may be used in a drug delivery device or a medical device. The film may be used for tissue engineering. We also provide a biocompatible composition in which are present a plurality of layers electrostatically self-assembled from at least a polymer or fullerene asmentioned. The substrate is not particulary limited, and may be quartz, glass, plastic, metal or ceramic, a material for a bone implant, bioactive glass, polyester or other polymers, plastic or rubber tubing, bandaging material, composite material, insulator material, semi-conductor material, an artificial hip, a pacemaker, a catheter, a stent or other substrates.
A process of making a substrate biocompatible comprising the steps of:
A biocompatible composition consisting essentially of:
A biocompatible composition comprising:
A biocompatible medical device or drug delivery device comprising:
A process of making a substrate biocompatible comprising the steps of:
A biocompatible material consisting essentially of a plurality of layers electrostatically self-assembled from a starting material that is a polymer, the layers deposited on a substrate comprising a material selected from the group consisting of ceramics, glasses, metals, metal alloys, plastics, and polymers;
A biocompatible material comprising a plurality of layers electrostatically self-assembled from a sting material that is a polymer, the layers deposited on a substrate comprising a material selected from the group consisting of ceramics, glasses, metals, metal alloys, plastics, and polymers;
A device for contacting a biological material, the device comprising:
Dependencies are inferred from the claim text.