EGFR ligands and methods of use
OwnerWaldemar Debinskiinventor
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Abstract
EGFR is over-expressed in malignant gliomas and, when activated, transduces apoptotic signals in these cancer cells. Chimeric molecules that contain an EGFR ligand and a carrier molecule are used to specifically target, and in some cases induce apoptosis in, EGFR-expressing cells.
Claims16
A chimeric molecule comprising an epidermal growth factor receptor ligand and a carrier molecule comprising a portion of an immunoglobulin molecule.
A chimeric molecule comprising an epidermal growth factor receptor ligand and a carrier molecule comprising PE40Δ553/Δ609-613.
A nucleic acid encoding a chimeric molecule comprising an epidermal growth factor receptor ligand and a carrier molecule comprising a portion of an immunoglobulin molecule or PE40Δ553/Δ609-613.
A method of inducing apoptosis in a cancer cell, the method comprising the step of administering a composition comprising a chimeric molecule comprising an epidermal growth factor receptor ligand and a carrier molecule in an amount effective to induce apoptosis in the cell.
Dependencies are inferred from the claim text.