Antibodies to biological membranes
OwnerCharles B Hensleyinventor
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Abstract
The present invention is directed toward antibodies specific for particular intracellular membrane components and the method of using these antibodies. In one aspect of the invention, injecting isolated membrane components into mice may generate specific antibodies to particular membrane components. The injection may include a membrane component by itself or in combination with another membrane component using an immunosuppression method. In one aspect of the invention, these antibodies are used as a novel method and system for drug delivery targeted to particular intracellular membrane components. Another aspect of the invention involves the use of these antibodies for identifying particular intracellular membrane components important for cell functions.
Claims16
An antibody specific to an intracellular membrane component, the antibody derived from a method comprising:
- isolating a particular intracellular membrane component;
- injecting the particular intracellular membrane component into mice;
- and
- harvesting the antibody produced by the mice.
An antibody specific to an intracellular membrane component, the antibody derived from a method comprising:
- isolating particular intracellular membrane components;
- injecting at least one animal with a first particular intracellular membrane component together with an immunosuppression agent;
- and
- followed by injecting said at least one animal with a second particular intracellular membrane component;
- without an immunosuppression agent.
A method of targeted drug delivery comprising:
- generating an antibody specific to an intracellular component of the cell,
- coupling the antibody to a membrane-crossing vector containing a therapeutic agent;
- delivering the therapeutic agent into the cell.
Dependencies are inferred from the claim text.