Methods of using cytokine antagonists to treat HIV infection and AIDS
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsEric S. Furfine, Neil Stahl
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Abstract
The invention is methods of using cytokine antagonists to treat HIV. In particular, the invention is methods of treating HIV using L-4 and IL-13 cytokine antagonists, including cytokine traps and anti-IL-4 or anti-IL-13 antibodies. The invention also includes augmenting the efficacy of HIV vaccination by co-administration of the vaccine with IL-4 and IL-13 cytokine antagonists.
Claims22
A method of treating HIV infection in a mammal comprising administering a cytokine antagonist to the mammal such that HIV infection is treated.
A method of augmenting the efficacy of HIV vaccination in a human comprising administering a cytokine antagonist to the human such that the efficacy of HIV vaccination is augmented.
A method of shifting the HIV vaccination-induced immune response in a human towards a Th1-type response comprising co-administration of a cytokine antagonist and the vaccine to the human such that HIV vaccination-induced immune response is shifted towards a Th1-type response.
A method of shifting the Th2-type immune response to a Th1-type immune response in an HIV-infected human comprising administering a cytokine antagonist to the human such that the Th-2-type response is shifted to a Th1-type response.
A method of inhibiting the Th2-type immune response in an HIV-infected human comprising administering a cytokine antagonist to the human such that the Th-2-type response is inhibited.
A method of treating HIV infection by administering an agent capable of blocking the activity of IL-4 and IL-13-mediated biological activity such that HIV infection is treated.
Dependencies are inferred from the claim text.