Method and apparatus for ion mobility spectrometry
AssigneeSiemens Aktiengesellschaft
InventorsKarsten Losch, Bengt Nolting
Life of this patent
Estimating the term…
Abstract
Molecular ions are generated by ionization, said molecular ions are accumulated in an ion reservoir that is external to the drift chamber. Than said molecular ions are dissociated into fragment ions (i.e. fragmented ions) with electromagnetic radiation or electron beams or ion beams, and said fragment ions are ion-mobility spectrometrically analyzed. In an embodiment the apparatus comprises additionally a virtual impactor and a pyrolyzer. The process of fragmentation over time are detected and analyzed, and this information is used for the differentiation of hazardous biological samples from non-hazardous biological samples.
Claims67
A method for ion-mobility spectrometry of a sample, comprising the steps of:
- (a) generating molecular ions by ionization and accumulating said molecular ions in an ion reservoir that is external to a drift chamber of an ion-mobility spectrometer;
- and
- (b) exposing said molecular ions in said ion reservoir to a source of energy for a time sufficient for dissociation of said ions into fragment ions prior to ion-mobility analysis in the drift chamber of the ion-mobility spectrometer, wherein said exposing results in production of multiple charge states of fragment ions.
An apparatus for ion mobility spectroscopy, comprising the parts of:
- (a) a virtual impactor;
- (b) a pyrolyzer;
- and
- (c) a ion mobility spectrometer, wherein generated ions of said sample are fragmented into fragment ions with one of electromagnetic radiation, electrons, and with ions, and said fragment ions are detected and analyzed.
Dependencies are inferred from the claim text.