Human genes, sequences and expression products
AssigneeHuman Genome Sciences, Inc.
InventorsPaul A. Moore, Reiner L. Gentz, Hongjun Ji, Jian Ni, Jing-Shan Hu
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Abstract
Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
Claims22
An isolated polynucleotide comprising a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:12;
- (b) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:13;
- (c) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:14;
- (d) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:15;
- (e) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:16;
- (f) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:17;
- (g) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:18;
- (h) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:19;
- (i) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:20;
- (j) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:21;
- (k) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:22;
- and
- (l) the complement of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), and (k).
An isolated polypeptide comprising a polypeptide having at least a 95% identity to a member selected form the group consisting of:
- (a) a polypeptide comprising the amino acid according to SEQ ID NO:12;
- (b) a polypeptide comprising the amino acid according to SEQ ID NO:13;
- (c) a polypeptide comprising the amino acid according to SEQ ID NO:14;
- (d) a polypeptide comprising the amino acid according to SEQ ID NO:15;
- (e) a polypeptide comprising the amino acid according to SEQ ID NO:16;
- (f) a polypeptide comprising the amino acid according to SEQ ID NO:17;
- (g) a polypeptide comprising the amino acid according to SEQ ID NO:18;
- (h) a polypeptide comprising the amino acid according to SEQ ID NO:19;
- (i) a polypeptide comprising the amino acid according to SEQ ID NO:20;
- (j) a polypeptide comprising the amino acid according to SEQ ID NO:21;
- and
- (k) a polypeptide comprising the amino acid according to SEQ ID NO:22.
Dependencies are inferred from the claim text.