Indazole benzimidazole compounds

A compound having the structure I, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer

• 102
• wherein
• Z1, Z2, Z3, and Z4 are independently selected from C or N;
• R1 is selected from —H, —F, —Cl, —Br, —NO2, —C≡N, —C(═O)—O-alkyl groups, —OH, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—SO2-alkyl groups, substituted and unsubstituted —N(H)—SO2-aryl groups, —N(H)—SO2-CF3 groups, substituted and unsubstituted —N(H)—SO2-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R2 is selected from —H, —F, —Cl, —Br, —C—N, —NO2, —CO2H, —OH, substituted and unsubstituted guanidinyl groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted —C(═O)O-alkyl groups, substituted and unsubstituted —C(═O)O-aryl groups, substituted and unsubstituted —C(═O)O-heteroaryl groups, substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)-alkyl groups, substituted and unsubstituted —N(H)C(═O)-aryl groups, substituted and unsubstituted —N(H)C(═O)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-alkyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-aryl groups, substituted and unsubstituted —N(H)C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —N(H)—(SO2)-alkyl groups, substituted and unsubstituted —N(H)—(SO2)-aryl groups, —N(H)—(SO2)—CF3 groups, substituted and unsubstituted —N(H)—(SO2)-heterocyclyl groups, substituted and unsubstituted —N(H)-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted akoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted heterocyclyloxy, substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• or R2 and R3 are a group of formula —OCH2O— such that R2 and R3 define a fused 5-membered ring that includes 2 oxygen atoms;
• R3 is selected from —F, —Cl, —Br, —CF3, —C≡N, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted saturated heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted saturated heterocycyl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—(SO2)-alkyl groups substituted and unsubstituted —N(H)—(SO2)-aryl groups, —N(H)—(SO2)—CF3 groups, substituted and unsubstituted —N(H)—(SO2)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-alkyl groups, and substituted and unsubstituted —N(H)C(═O)N(H)-aryl;
• R4 is —H, —F, —Br, —Cl, —NO2, —C≡N, —C(═O)—O-alkyl groups, —OH, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—SO2-alkyl groups, substituted and unsubstituted —N(H)—SO2-aryl groups, —N(H)—SO2-CF3 groups, substituted and unsubstituted —N(H)—SO2-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R5 is selected from —H, —F, —Cl, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkylamino groups, substituted and unsubstituted dialkylamino groups, and substituted and unsubstituted heterocyclyl groups, or R5 is absent if Z1 is N;
• R6 is selected from —H, —F, —Cl, —Br, —CF3, —CO2H, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups including substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted arylalkoxy groups, and substituted and unsubstituted alkoxyalkoxy groups;
• substituted and unsubstituted heterocyclyl groups including substituted and unsubstituted heterocyclylheterocyclyl groups, substituted and unsubstituted arylheterocyclyl groups, substituted and unsubstituted alkylheterocyclyl groups, and substituted and unsubstituted cycloalkylheterocyclyl groups;
• substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted amino groups including substituted and unsubstituted dialkylamino groups, substituted and unsubstituted (alkyl)(heterocyclyl)amino groups, substituted and unsubstituted heterocyclylalkylamino groups, substituted and unsubstituted arylalkylamino groups, and substituted and unsubstituted heterocyclylamino groups;
• substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —C(═O)N(alkyl)(heterocyclyl) groups, and substituted and unsubstituted —C(═O)-heterocyclyl groups;
• or R6 is absent if Z2 is N;
• R7 is selected from —H, —F, —Cl, —Br, —CF3, —CO2H, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups including substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted arylalkoxy groups, and substituted and unsubstituted alkoxyalkoxy groups;
• substituted and unsubstituted heterocyclyl groups including substituted and unsubstituted heterocyclylheterocyclyl groups, substituted and unsubstituted arylheterocyclyl groups, substituted and unsubstituted alkylheterocyclyl groups, and substituted and unsubstituted cycloalkylheterocyclyl groups;
• substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted amino groups including substituted and unsubstituted dialkylamino groups, substituted and unsubstituted (alkyl)(heterocyclyl)amino groups, substituted and unsubstituted heterocyclylalkylamino groups, substituted and unsubstituted arylalkylamino groups, and substituted and unsubstituted heterocyclylamino groups;
• substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —C(═O)N(alkyl)(heterocyclyl) groups, and substituted and unsubstituted —C(═O)-heterocyclyl groups;
• or R7 is absent if Z3 is N;
• R8 is selected from —H, —F, —Cl, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkylamino groups, substituted and unsubstituted dialkylamino groups, and substituted and unsubstituted heterocyclyl groups, or R8 is absent if Z4 is N;
• R9 is —H;
• and
• R10 is selected from the group consisting of —H, and substituted and unsubstituted alkyl groups.

A compound having the structure I, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer

• 103
• wherein p2 Z1, Z2, Z3, and Z4 are independently selected from C or N;
• R1 is selected from —H, —F, —Cl, —Br, —NO2, —C≡N, —C(═O)—O-alkyl groups, —OH, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—SO2-alkyl groups, substituted and unsubstituted —N(H)—SO2-aryl groups, —N(H)—SO2-CF3 groups, substituted and unsubstituted —N(H)—SO2-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R2 is selected from —F, —Cl, —Br, —C≡N, —CO2H, —OH, substituted and unsubstituted guanidinyl groups,substituted and unsubstituted —C(═O)O-alkyl groups, substituted and unsubstituted —C(═O)O-aryl groups, substituted and unsubstituted —C(═O)O-heteroaryl groups, substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)-alkyl groups, substituted and unsubstituted —N(H)C(═O)-aryl groups, substituted and unsubstituted —N(H)C(═O)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-alkyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-aryl groups, substituted and unsubstituted —N(H)C(═O)N(H)-heterocyclyl groups,substituted and unsubstituted —N(H)—(SO2)-alkyl groups, substituted and unsubstituted —N(H)—(SO2)-aryl groups, —N(H)—(SO2)—CF3 groups, substituted and unsubstituted —N(H)—(SO2)-heterocyclyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted heterocyclyloxy, and substituted and unsubstituted heterocyclylalkoxy groups;
• or R2 and R3 are a group of formula —OCH2O— such that R2 and R3 define a fused 5-membered ring that includes 2 oxygen atoms;
• R3 is selected from —H, —F, —Cl, —Br, —CF3, —C≡N, —NO2, —CO2H, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted —C(═O)—O-alkyl groups, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy group, substituted and unsubstituted heterocycyl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—(SO2)-alkyl groups substituted and unsubstituted —N(H)—(SO2)-aryl groups, —N(H)—(SO2)—CF3 groups, substituted and unsubstituted —N(H)—(SO2)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-alkyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R4 is —H1-F, —Br, —Cl, —NO2, —C≡N, —C(═O)—O-alkyl groups, —OH, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—SO2-alkyl groups, substituted and unsubstituted —N(H)—SO2-aryl groups, —N(H)—SO2-CF3 groups, substituted and unsubstituted —N(H)—SO2-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R5 is selected from —H, —F, —Cl, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkylamino groups, substituted and unsubstituted dialkylamino groups, and substituted and unsubstituted heterocyclyl groups, or R5 is absent if Z1 is N;
• R6 is selected from —H, —F, —Cl, —Br, —CF3, —CO2H, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups including substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted arylalkoxy groups, and substituted and unsubstituted alkoxyalkoxy groups;
• substituted and unsubstituted heterocyclyl groups including substituted and unsubstituted heterocyclylheterocyclyl groups, substituted and unsubstituted arylheterocyclyl groups, substituted and unsubstituted alkylheterocyclyl groups, and substituted and unsubstituted cycloalkylheterocyclyl groups;
• substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted amino groups including substituted and unsubstituted dialkylamino groups, substituted and unsubstituted (alkyl)(heterocyclyl)amino groups, substituted and unsubstituted heterocyclylalkylamino groups, substituted and unsubstituted arylalkylamino groups, and substituted and unsubstituted heterocyclylamino groups;
• substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —C(═O)N(alkyl)(heterocyclyl) groups, and substituted and unsubstituted —C(═O)-heterocyclyl groups;
• or R6 is absent if Z2 is N;
• R7 is selected from —H, —F, —Cl, —Br, —CF3, —CO2H, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups including substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted arylalkoxy groups, and substituted and unsubstituted alkoxyalkoxy groups;
• substituted and unsubstituted heterocyclyl groups including substituted and unsubstituted heterocyclylheterocyclyl groups, substituted and unsubstituted arylheterocyclyl groups, substituted and unsubstituted alkylheterocyclyl groups, and substituted and unsubstituted cycloalkylheterocyclyl groups;
• substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted amino groups including substituted and unsubstituted dialkylamino groups, substituted and unsubstituted (alkyl)(heterocyclyl)amino groups, substituted and unsubstituted heterocyclylalkylamino groups, substituted and unsubstituted arylalkylamino groups, and substituted and unsubstituted heterocyclylamino groups;
• substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —C(═O)N(alkyl)(heterocyclyl) groups, and substituted and unsubstituted —C(═O)-heterocyclyl groups;
• or R7 is absent if Z3 is N;
• R8 is selected from —H, —F, —Cl, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkylamino groups, substituted and unsubstituted dialkylamino groups, and substituted and unsubstituted heterocyclyl groups, or R8 is absent if Z4 is N;
• R9 is —H;
• and
• R10 is selected from the group consisting of —H, and substituted and unsubstituted alkyl groups.

A compound having the structure I, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer

• 104
• wherein
• Z1, Z2, Z3, and Z4 are independently selected from C or N;
• R1 is selected from —H, —F, —Cl, —Br, —NO2, —C≡N, —C(═O)—O-alkyl groups, —OH, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—SO2-alkyl groups, substituted and unsubstituted —N(H)—SO2-aryl groups, —N(H)—SO2-CF3 groups, substituted and unsubstituted —N(H)—SO2-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R2 is selected from —H, —F, —Cl, —Br, —C≡N, —NO2, —CO2H, —OH, substituted and unsubstituted guanidinyl groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted —C(═O)O-alkyl groups, substituted and unsubstituted —C(═O)O-aryl groups, substituted and unsubstituted —C(═O)O-heteroaryl groups, substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)-alkyl groups, substituted and unsubstituted —N(H)C(═O)-aryl groups, substituted and unsubstituted —N(H)C(═O)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-alkyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-aryl groups, substituted and unsubstituted —N(H)C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —N(H)—(SO2)-alkyl groups, substituted and unsubstituted —N(H)—(SO2)-aryl groups, —N(H)—(SO2)—CF3 groups, substituted and unsubstituted —N(H)—(SO2)-heterocyclyl groups, substituted and unsubstituted —N(H)-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted akoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted heterocyclyloxy, substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• or R2 and R3 are a group of formula —OCH2O— such that R2 and R3 define a fused 5-membered ring that includes 2 oxygen atoms;
• R3 is selected from —H, —F, —Cl, —Br, —CF3, —C≡N, —NO2, —CO2H, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted —C(═O)—O-alkyl groups, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy group, substituted and unsubstituted heterocycyl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—(SO2)-alkyl groups substituted and unsubstituted —N(H)—(SO2)-aryl groups, —N(H)—(SO2)—CF3 groups, substituted and unsubstituted —N(H)—(SO2)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-alkyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R4 is —H, —F, —Br, —Cl, —NO2, —C≡N, —C(═O)—O-alkyl groups, —OH, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—SO2-alkyl groups, substituted and unsubstituted —N(H)—SO2-aryl groups, —N(H)—SO2-CF3 groups, substituted and unsubstituted —N(H)—SO2-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R5 is selected from —H, —F, —Cl, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkylamino groups, substituted and unsubstituted dialkylamino groups, and substituted and unsubstituted heterocyclyl groups, or R5 is absent if Z1 is N;
• R6 is selected from —H, —F, —Cl, —Br, —CF3, —CO2H, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups including substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted arylalkoxy groups, and substituted and unsubstituted alkoxyalkoxy groups;
• substituted and unsubstituted heterocyclyl groups including substituted and unsubstituted heterocyclylheterocyclyl groups, substituted and unsubstituted arylheterocyclyl groups, substituted and unsubstituted alkylheterocyclyl groups, and substituted and unsubstituted cycloalkylheterocyclyl groups;
• substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted amino groups including substituted and unsubstituted dialkylamino groups, substituted and unsubstituted (alkyl)(heterocyclyl)amino groups, substituted and unsubstituted heterocyclylalkylamino groups, substituted and unsubstituted arylalkylamino groups, and substituted and unsubstituted heterocyclylamino groups;
• substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —C(═O)N(alkyl)(heterocyclyl) groups, and substituted and unsubstituted —C(═O)-heterocyclyl groups;
• or R6 is absent if Z2 is N;
• R7 is selected from —H, —F, —Cl, —Br, —CF3, —CO2H, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups including substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted arylalkoxy groups, and substituted and unsubstituted alkoxyalkoxy groups;
• substituted and unsubstituted heterocyclyl groups including substituted and unsubstituted heterocyclylheterocyclyl groups, substituted and unsubstituted arylheterocyclyl groups, substituted and unsubstituted alkylheterocyclyl groups, and substituted and unsubstituted cycloalkylheterocyclyl groups;
• substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted amino groups including substituted and unsubstituted dialkylamino groups, substituted and unsubstituted (alkyl)(heterocyclyl)amino groups, substituted and unsubstituted heterocyclylalkylamino groups, substituted and unsubstituted arylalkylamino groups, and substituted and unsubstituted heterocyclylamino groups;
• substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —C(═O)N(alkyl)(heterocyclyl) groups, and substituted and unsubstituted —C(═O)-heterocyclyl groups;
• or R7 is absent if Z3 is N;
• R8 is selected from —H, —F, —Cl, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkylamino groups, substituted and unsubstituted dialkylamino groups, and substituted and unsubstituted heterocyclyl groups, or R8 is absent if Z4 is N;
• R9 is —H;
• and
• R10 is selected from the group consisting of —H, and substituted and unsubstituted alkyl groups, and further wherein at least one of Z2 or Z3 is C and at least one of R6 or R7 is selected from the group consisting of substituted and unsubstituted piperidinyl substituted heterocyclyl groups, substituted and unsubstituted heterocyclyl substituted piperidinyl groups, substituted and unsubstituted hydroxymethyl substituted piperidinyl groups, dimethylaminoalkyl substituted pyrrolidinyl groups, substituted and unsubstituted 3-alkyl substituted piperazinyl groups, substituted and unsubstituted 3,5-dialkyl substituted piperazinyl groups, substituted and unsubstituted N-hydroxyalkyl substituted piperazinyl groups, substituted and unsubstituted 1,4-diazacycloheptyl groups, substituted and unsubstituted 1-aza-4-oxacycloheptane groups, substituted and unsubstituted N-ethylpiperazinyl groups, substituted and unsubstituted N-isopropylpiperazinyl groups, substituted and unsubstituted N-sec-butylpiperazinyl groups, substituted and unsubstituted N-2-pyridyl substituted piperazinyl groups, substituted and unsubstituted N-3-pyridyl substituted piperazinyl groups, substituted and unsubstituted N-4-pyridyl substituted piperazinyl groups, substituted and unsubstituted N(H)—CH2-pyridyl groups, substituted and unsubstituted imidazolyl groups, substituted and unsubstituted 3-alkyl substituted morpholinyl groups, substituted and unsubstituted 3,5-dialkyl substituted morpholinyl groups, dialkylamino substituted pyrrolidinyl groups, pyrrolidinyl groups substituted with both dialkylamino and alkyl groups, substituted and unsubstituted 4-hydroxy substituted piperidinyl groups, substituted and unsubstituted 4-aryl substituted piperidinyl groups, substituted and unsubstituted 4-hydroxy-4-phenyl substituted piperidinyl groups, substituted and unsubstituted cyclohexylpiperazinyl groups, substituted and unsubstituted cyclopentylpiperazinyl groups, substituted and unsubstituted N-alkyl substituted diazabicycloalkane groups, substituted and unsubstituted —N(CH3)(N-alkyl(4-piperidinyl)) groups, substituted and unsubstituted piperazinyl groups further substituted with a —C(═O)-alkyl group bonded to one of the N atoms of the piperazinyl group, substituted and unsubstituted —N(H)CH2CH2CH2-imidazolyl groups, substituted and unsubstituted —N(H)CH2CH2CH2-pyrrolidinyl groups, substituted and unsubstituted —N(H)CH2CH2CH2-morpholinyl groups, substituted and unsubstituted —N(H)CH2CH2CH2-piperazinyl groups, substituted and unsubstituted —N(H)CH2CH2CH2-piperidinyl groups, substituted and unsubstituted —N(H)CH2CH2CH2-pyridyl groups, substituted and unsubstituted —N(H)CH2CH2-imidazolyl groups, substituted and unsubstituted —N(H)CH2CH2-pyrrolidinyl groups, substituted and unsubstituted —N(H)CH2CH2-morpholinyl groups, substituted and unsubstituted —N(H)CH2CH2-piperazinyl groups, substituted and unsubstituted —N(H)CH2CH2-piperidinyl groups, substituted and unsubstituted —N(H)CH2CH2-pyridyl groups, substituted and unsubstituted cyclobutylpiperazinyl groups, substituted and unsubstituted —OCH2-pyrrolidinyl groups, substituted and unsubstituted —OCH2CH2-pyrrolidinyl groups, substituted and unsubstituted-OCH2CH2CH2-pyrrolidinyl groups, substituted and unsubstituted piperazinyl groups further substituted with a —CH2C(═O)—O-alkyl group bonded to one of the N atoms of the piperazinyl group, substituted and unsubstituted piperazinyl groups further substituted with a —C(═O)—O-alkyl group bonded to one of the N atoms of the piperazinyl group, substituted and unsubstituted hydroxypyrrolidinyl groups, substituted and unsubstituted hydroxypiperidinyl groups, substituted and unsubstituted —OCH2-pyridyl groups, substituted and unsubstituted piperidinylamino groups, substituted and unsubstituted pyridyloxy groups with a —C(═O)—N(H)(alkyl) group bonded to a carbon atom of the pyridine ring of the pyridyloxy group, and substituted and unsubstituted pyridyloxy groups with a —C(═O)—N(alkyl)2 group bonded to a carbon atom of the pyridine ring of the pyridyloxy group.

A compound having the structure I, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer

• 105
• wherein
• Z1, Z2, Z3, and Z4 are independently selected from C or N;
• R1 is selected from —H, —F, —Cl, —Br, —NO2, —C≡N, —C(═O)—O-alkyl groups, —OH, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—SO2-alkyl groups, substituted and unsubstituted —N(H)—SO2-aryl groups, —N(H)—SO2-CF3 groups, substituted and unsubstituted —N(H)—SO2-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R2 is selected from —H, —F, —Cl, —Br, —C—N, —NO2, —CO2H, —OH, substituted and unsubstituted guanidinyl groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted —C(═O)O-alkyl groups, substituted and unsubstituted —C(═O)O-aryl groups, substituted and unsubstituted —C(═O)O-heteroaryl groups, substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)-alkyl groups, substituted and unsubstituted —N(H)C(═O)-aryl groups, substituted and unsubstituted —N(H)C(═O)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-alkyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-aryl groups, substituted and unsubstituted —N(H)C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —N(H)—(SO2)-alkyl groups, substituted and unsubstituted —N(H)—(SO2)-aryl groups, —N(H)—(SO2)—CF3 groups, substituted and unsubstituted —N(H)—(SO2)-heterocyclyl groups, substituted and unsubstituted —N(H)-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted akoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted heterocyclyloxy, substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• or R2 and R3 are a group of formula —OCH2O— such that R2 and R3 define a fused 5-membered ring that includes 2 oxygen atoms;
• R3 is selected from —H, —F, —Cl, —Br, —CF3, —C≡N, —NO2, —CO2H, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted —C(═O)—O-alkyl groups, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy group, substituted and unsubstituted heterocycyl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—(SO2)-alkyl groups substituted and unsubstituted —N(H)—(SO2)-aryl groups, —N(H)—(SO2)—CF3 groups, substituted and unsubstituted —N(H)—(SO2)-heterocyclyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-alkyl groups, substituted and unsubstituted —N(H)C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R4 is —H, —F, —Br, —Cl, —NO2, —C≡N, —C(═O)—O-alkyl groups, —OH, substituted and unsubstituted arylalkoxy groups, substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted alkoxyalkyl groups, substituted and unsubstituted arylalkoxyalkyl groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted —N(H)—C(═O)-aryl groups, substituted and unsubstituted —N(H)—C(═O)-alkyl groups, substituted and unsubstituted —N(H)—SO2-alkyl groups, substituted and unsubstituted —N(H)—SO2-aryl groups, —N(H)—SO2-CF3 groups, substituted and unsubstituted —N(H)—SO2-heterocyclyl groups, substituted and unsubstituted heterocyclyl groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted —C(═O)—N(H)-alkyl groups, substituted and unsubstituted —C(═O)—N(H)-alkyl-heterocyclyl groups, substituted and unsubstituted (alkyl)(alkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(aryl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclyl)aminoalkyl groups substituted and unsubstituted (alkyl)(arylalkyl)aminoalkyl groups, substituted and unsubstituted (alkyl)(heterocyclylalkyl)aminoalkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-aryl groups, substituted and unsubstituted-alkyl—N(alkyl)—C(═O)-alkyl-heterocyclyl groups, substituted and unsubstituted alkylaminoalkyl groups, substituted and unsubstituted arylaminoalkyl groups, substituted and unsubstituted heterocyclylaminoalkyl groups substituted and unsubstituted arylalkylaminoalkyl groups, substituted and unsubstituted heterocyclylalkylaminoalkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-aryl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-heterocyclyl groups, substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-aryl groups, and substituted and unsubstituted-alkyl—N(H)—C(═O)-alkyl-heterocyclyl groups;
• R5 is selected from —H, —F, —Cl, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkylamino groups, substituted and unsubstituted dialkylamino groups, and substituted and unsubstituted heterocyclyl groups, or R5 is absent if Z1 is N;
• R6 is selected from —H, —F, —Cl, —Br, —CF3, —CO2H, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups including substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted arylalkoxy groups, and substituted and unsubstituted alkoxyalkoxy groups;
• substituted and unsubstituted heterocyclyl groups including substituted and unsubstituted heterocyclylheterocyclyl groups, substituted and unsubstituted arylheterocyclyl groups, substituted and unsubstituted alkylheterocyclyl groups, and substituted and unsubstituted cycloalkylheterocyclyl groups;
• substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted amino groups including substituted and unsubstituted dialkylamino groups, substituted and unsubstituted (alkyl)(heterocyclyl)amino groups, substituted and unsubstituted heterocyclylalkylamino groups, substituted and unsubstituted arylalkylamino groups, and substituted and unsubstituted heterocyclylamino groups;
• substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —C(═O)N(alkyl)(heterocyclyl) groups, and substituted and unsubstituted —C(═O)-heterocyclyl groups;
• or R6 is absent if Z2 is N;
• R7 is selected from —H, —F, —Cl, —Br, —CF3, —CO2H, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups including substituted and unsubstituted heterocyclylalkoxy groups, substituted and unsubstituted arylalkoxy groups, and substituted and unsubstituted alkoxyalkoxy groups;
• substituted and unsubstituted heterocyclyl groups including substituted and unsubstituted heterocyclylheterocyclyl groups, substituted and unsubstituted arylheterocyclyl groups, substituted and unsubstituted alkylheterocyclyl groups, and substituted and unsubstituted cycloalkylheterocyclyl.groups;
• substituted and unsubstituted heterocyclyloxy groups, substituted and unsubstituted aryloxy groups, substituted and unsubstituted amino groups including substituted and unsubstituted dialkylamino groups, substituted and unsubstituted (alkyl)(heterocyclyl)amino groups, substituted and unsubstituted heterocyclylalkylamino groups, substituted and unsubstituted arylalkylamino groups, and substituted and unsubstituted heterocyclylamino groups;
• substituted and unsubstituted —C(═O)N(H)-alkyl groups, substituted and unsubstituted —C(═O)N(H)-aryl groups, substituted and unsubstituted —C(═O)N(H)-heterocyclyl groups, substituted and unsubstituted —C(═O)N(alkyl)(heterocyclyl) groups, and substituted and unsubstituted —C(═O)-heterocyclyl groups;
• or R7 is absent if Z3 is N;
• R8 is selected from —H, —F, —Cl, substituted and unsubstituted alkyl groups, substituted and unsubstituted alkoxy groups, substituted and unsubstituted amino groups, substituted and unsubstituted alkylamino groups, substituted and unsubstituted dialkylamino groups, and substituted and unsubstituted heterocyclyl groups, or R8 is absent if Z4 is N;
• R9 is —H;
• and
• R10 is selected from the group consisting of —H, and substituted and unsubstituted alkyl groups,
• and further wherein at least one of the following is true:
• (i) R1 is selected from the group consisting of unsubstituted —NH2 groups, and substituted and unsubstituted pyrrolidinylalkylamino groups;
• (ii) R2 is selected from the group consisting of substituted and unsubstituted thiazolylalkylamino groups, substituted and unsubstituted pyrrolidinylalkylamino groups, and substituted and unsubstituted aminoalkylamino groups;
• or
• (iii) R3 is selected from the group consisting of substituted and unsubstituted thiazolylalkylamino groups, substituted and unsubstituted benzimidazolylalkylamino groups, substituted and unsubstituted imidazolylalkylamino groups, substituted and unsubstituted furanylalkylamino groups, and substituted and unsubstituted arylalkylamino groups.