IgA nephropathy-related DNA
AssigneeNihon University
InventorsTetsuyoshi Ishiwata, Mikiko Sakurada, Ayako Kawabata, Satoshi Nakagawa, Tatsunari Nishi, Tetsuro Kuga, Shigemasa Sawada, Masami Takei, Kenji Shibata, Akiko Furuya
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Abstract
A novel DNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, methods for detecting the protein and the DNA, and methods of diagnosis and treatment of IgA nephropathy.
Claims21
A DNA related to IgA nephropathy comprising a nucleotide sequence selected from the nucleotide sequences represented by SEQ ID NO:1 to NO:33 and SEQ ID NO:41 to NO:44, or, a DNA which hybridizes with said DNA under stringent conditions.
A DNA comprising a nucleotide sequence identical to continuous 5 to 60 residues in a nucleotide sequence selected from the nucleotide sequences represented by SEQ ID NO:1 to NO:33, or a DNA comprising a sequence complementary to said DNA.
A method for isolating a DNA related to IgA nephropathy from leukocytes of a patient with IgA nephropathy comprising conducting a differential display method.
A protein comprising an amino acid sequence selected from the amino acid sequences represented by SEQ ID NO:34 to NO:40, or a protein comprising an amino acid sequence in which one or several amino acids are deleted, substituted or added in the amino acid sequence of said protein, and having an activity related to IgA nephropathy.
Dependencies are inferred from the claim text.