US 2003/0207348 A1Published application

Polypeptides and polynucleotides encoding same

OwnerRichard A. Shimkets, Elma R. Fernandes +7inventors

InventorsRichard A. Shimkets, Elma R. Fernandes, Li Li, Linda Gorman, Vladimir Y. Gusev, Muralidhara Padigaru, Meera Patturajan, Suresh G. Shenoy, Kimberly A. Spytek

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Abstract

The invention provides polypeptides, designated herein as SECP polypeptides, as well as polynucleotides encoding SECP polypeptides, and antibodies that immunospecifically-bind to SECP polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the SECP polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.

Claims41

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57 wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57;
and
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57 wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence.

2 more elements

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57 wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57;
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57 wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
(e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising an amino acid sequence chosen from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 41, 43, 45, 47, 49, 51, 53, 55 and 57 or a variant of said polypeptide, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
and
(f) a nucleic acid molecule comprising the complement of (a), (b), (c), (d) or (e).

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/074,566Filed 13 Feb 2002
Priority: 20 Jul 1999
Published: 6 Nov 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07K 14/4703
Regulators; Modulating activity: inhibitors; Suppressors
C07K 14/47
From vertebrates: from mammals
C07K 14/575
From animals; from humans: hormones
C07K 14/705
From animals; from humans: receptors; Cell surface antigens; Cell surface determinants

Family

Application60/144,722Us provisional application · filed 20 Jul 1999
Application60/167,785Us provisional application · filed 29 Nov 1999
Application09/619,252Continuation in part · filed 19 Jul 2000
Application60/276,994Us provisional application · filed 19 Mar 2001
Application60/280,898Us provisional application · filed 2 Apr 2001
Application60/288,062Us provisional application · filed 2 May 2001
Application60/291,766Us provisional application · filed 17 May 2001
Application60/314,007Us provisional application · filed 21 Aug 2001
Application60/332,241Us provisional application · filed 14 Nov 2001
Application10/074,566Continuation in part · filed 13 Feb 2002
US 2003/0207348 A1This patent

From the US filing history. Foreign family members aren’t listed.