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US 2003/0207257 A1Published application
Diffraction-based diagnostic devices
AssigneeKimberly-Clark Worldwide, Inc.
InventorsDavid Cohen, Rosann Kaylor
Life of this patent
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Abstract
A biosensor includes a substrate with areas of active receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of the active areas is defined on the substrate by an oxidizing photo-masking process.
Claims35
A method for producing biosensors, comprising:
- forming a blocking layer of thiol-containing molecules on a metalized substrate member, the thiol-containing molecules forming thiol-metal bonds with the metal surface of the substrate member;
- exposing the substrate member to an oxidizing enhancing stimulus through a mask having a pattern of exposed areas and protected areas, said exposure being of sufficient time to oxidize the thiol-metal bonds in the exposed areas of the blocking layer under the mask;
- and
- exposing the substrate member to a first source of thiolated biomolecules for a time sufficient for a layer of the first thiolated biomolecules to form at the oxidized areas of the blocking layer.
1 more element
A biosensor, comprising:
- a metalized substrate member;
- a pattern of areas of first thiolated biomolecules defined on said substrate member, said pattern formed by oxidizing a blocking layer previously applied to said substrate in a masking process wherein the blocking layer is exposed to an oxidizing enhancing stimulus through a mask having a pattern of exposed areas and protected areas, said exposure being of sufficient time to oxidize thiol-metal bonds in the exposed areas of said blocking layer under said mask;
- and subsequently exposing said substrate member to a source of said thiolated biomolecules for a time sufficient for a layer of said thiolated biomolecules to form at the oxidized areas of the blocking layer.
Dependencies are inferred from the claim text.