Compositions and methods for the therapy and diagnosis of ovarian cancer
AssigneeCorixa Corporation
InventorsGary R. Fanger, Steven P. Fling
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Abstract
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
Claims17
An isolated polynucleotide comprising a sequence selected from the group consisting of:
- (a) SEQ ID NO:
- 214;
- (b) the complement SEQ ID NO:214;
- (c) a sequence consisting of at least 20 contiguous residues of SEQ ID NO:214;
- (d) sequences that hybridize to a SEQ ID NO:214 under moderately stringent conditions;
- (e) a sequence having at least 75% identity to SEQ ID NO:214;
- (f) a sequence having at least 90% identity SEQ ID NO:214 and (g) a degenerate variant of SEQ ID NO:214.
An oligonucleotide that hybridizes to SEQ ID NO:214 under moderately stringent conditions.
Dependencies are inferred from the claim text.