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AssigneePharmacia Corporation
InventorsGordon H. Williams, John W. Funder, Susan M. Garthwaite, Barbara Roniker, Kenton N. Fedde, Ricardo Rocha
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The present invention provides methods for the treatment or prophylaxis of one or more aldosterone-mediated pathogenic effects in a subject suffering from or susceptible to the pathogenic effect or effects wherein the subject has one or more conditions selected from the group consisting of a sub-normal endogenous aldosterone level, salt sensitivity and an elevated dietary sodium intake. The methods comprise administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds that are aldosterone antagonists.
A method for the treatment or prophylaxis of one or more aldosterone-mediated pathogenic effects in a human subject suffering from or susceptible to the pathogenic effect or effects, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds, wherein the subject has one or more conditions selected from the group consisting of a sub-normal endogenous aldosterone level, salt sensitivity and an elevated dietary sodium intake, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for the treatment or prophylaxis of hypertension in a human subject suffering from or susceptible to hypertension, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds, wherein the subject has salt sensitivity or an elevated dietary sodium intake, or both, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for the treatment or prophylaxis of cardiovascular disease in a human subject suffering from or susceptible to cardiovascular disease, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds, wherein the subject has salt sensitivity or an elevated dietary sodium intake, or both, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for the treatment or prophylaxis of heart failure in a human subject suffering from or susceptible to cardiovascular disease, the method comprising administering to the subject a therapeutically-effective amount of an ACE inhibitor, a loop diuretic, and one or more epoxy-steroidal compounds, wherein the subject has salt sensitivity or an elevated dietary sodium intake, or both, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for the prophylaxis of one or more aldosterone-mediated pathogenic effects in a human subject suffering from or susceptible to the pathogenic effect or effects, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds,
A method for the treatment or prophylaxis of salt sensitivity in a human subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for reducing sodium appetite in a human subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for reducing or reversing the progression of salt sensitivity in a human subject suffering from or susceptible to salt sensitivity, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for the treatment or prophylaxis of a human subject to reduce or prevent one or more pathogenic effects resulting, in whole or in part, from aberrant aldosterone levels in brain, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds, wherein the subject has salt sensitivity or an elevated dietary sodium intake, or both, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for the treatment or prophylaxis of a human subject to reduce or prevent one or more pathogenic effects resulting, in whole or in part, from aberrant sodium retention in the kidney, the method comprising administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds, wherein the subject has salt sensitivity or an elevated dietary sodium intake, or both, and wherein the epoxy-steroidal compounds are aldosterone antagonists.
A method for the treatment of salt sensitive hypertension in a human subject in need thereof, the method comprising administering to the subject an therapeutically-effective amount of eplerenone.
A method for the treatment of salt sensitive heart failure in a human subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of eplerenone.
Dependencies are inferred from the claim text.