Screening method for SREBP pathway-specific inhibitors
AssigneesChugai Seiyaku Kabushiki Kaisha, Trustees of Dartmouth College
InventorsChang Ta-Yuan, Tatsuhiko Kodama, Takao Hamakubo, Yoshiki Kawabe
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Abstract
This invention provides a screening method for sterol regulatory element binding protein (SREBP) pathway-specific inhibitors using a mutant cultured cell, as well as therapeutic agents for hyperlipemia, arterial sclerosis, obesity or cancer containing an SREBP pathway-specific inhibitor selected by said screening method.
Claims13
The screening method for sterol regulatory element binding protein (SREBP) pathway specific inhibitors, which comprises using a cell in which a chimeric gene of a reporter gene and the gene encoding the C-terminus of SREBP has been expressed.
A vector obtained by inserting a chimeric gene of a reporter gene and the gene encoding the C-terminus of SREBP into a reporter gene expression vector.
A vector obtained by inserting a chimeric gene of a reporter gene and a gene encoding the stretch from the first transmembrane domain of SREBP to the cleavage site with SREBP Site 1 protease (S1P) into a reporter gene expression vector.
Dependencies are inferred from the claim text.