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US 2003/0201160 A1Published application
Removal of adenine during a process of pathogen reducing blood and blood components
AssigneeGambro AB
InventorsRaymond P. Goodrich, Suzann K. Doane
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Abstract
The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced.
Claims27
A method for treating a fluid to reduce pathogens which may be present therein, the fluid containing one or more components selected from the group consisting of blood and blood components, the method comprising:
- (a) removing substantially all adenine from the fluid;
- (b) mixing a pathogen reduction-effective, substantially non-toxic amount of an endogenous photosensitizer or endogenously-based derivative photosensitizer with the fluid;
- (c) exposing the fluid containing the photosensitizer to photoradiation of sufficient wavelength and energy to activate the photosensitizer, whereby the pathogens are reduced.
A fluid for pathogen reduction that is substantially adenine-free comprising:
- one or more components selected from the group consisting of blood and blood components;
- an endogenous photosensitizer or an endogenously-based derivative photosensitizer;
- and
- an adenine-free solution.
1 more element
Dependencies are inferred from the claim text.