Carbamic acid esters as inhibitors of factor xa

Compounds of the formula I

• 20
• in which
• R is —CO—N═C(NH2)2, —NH—C(═NH)—NH2 or —C(═NH)—NH2, which may also be monosubstituted by OH, —OCOOA, —OCOO(CH2)nNAA′, —COO(CH2)NAA′, —OCOO(CH2)m-Het, —COO(CH2)m-Het, —CO—CAA′-R3, —COO—CAA′-R3, COOA, COSA, COOAr or COOAr′ or by a conventional amino-protecting group,
• 21
• R′ is unbranched, branched or cyclic alkyl having 1-20 carbon atoms, in which one or two CH2 groups may be replaced by O or S atoms, or is Ar, Ar′ or X,
• R2 is phenyl which is monosubstituted by S(O)pA, S(O)pNHA, CF3, COOA, CH2NHA, CN or OA,
• R3 is —C(Hal)3, —O(C═O)A or
• 22
• Ar is phenyl or naphthyl which is unsubstituted or monosubstituted, disubstituted or trisubstituted by A, OA, NAA′, NO2, CF3, CN, Hal, NHCOA, COOA, CONAA′, S(O)pA or S(O)pNAA′,
• Ar′ is —(CH2)n-Ar,
• A and A′ are each, independently of one another, H or unbranched, branched or cyclic alkyl having 1-20 carbon atoms,
• Het is a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic radical having 1 to 4 N, O and/or S atoms, bonded via N or C, which may be unsubstituted or substituted by A,
• X is —(CH2)n—Y,
• Y is COOA or
• 23
• Hal is F, Cl, Br or 1,
• m is 0 or 1,
• n is 1, 2, 3, 4, 5 or 6, and
• p 0, 1 or 2,
• and their pharmaceutically tolerated salts and solvates.