US 2003/0199697 A1 · METHOD FOR THE TREATMENT OF MALARIA BY THE USE OF PRIMAQUINE DERIVATIVE N1-(3-ETHYLIDINOTETRAHYDROFURAN-2-ONE) -N 4-(6-METHOXY-8-QUINOLINYL)-1,4-PENTANEDIAMINE AS GAMETOCYTOCIDAL AGENT

Method for the treatment of malaria by the use of primaquine derivative n1-(3-ethylidinotetrahydrofuran-2-one) -n 4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as gametocytocidal agent

AssigneeCouncil of Scientific and Industrial Research

InventorsRAM PRATAP, AMIYA PRASAD BHADURI, HARSH PATI THAPLIYAL, SUNIL KUMAR PURI, GURU PRASAD DUTTA, ANIL KUMAR DWIVEDI, SATYAWAN SINGH, PRATIMA SRIVASTAVA, VIKASH CHANDRA PANDEY, SUDHIR SRIVASTAVA, SHIO KUMAR SINGH, RAM CHANDRA GUPTA, JAGDISHWAR SAHAI SRIVASTAVA, OMKAR PRASAD ASTHANA

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Abstract

The present invention a novel use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and contolling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.

Claims10

Dependent claims

A method of treatment of malaria in animals, particularly humans which comprises administering to said animals, particularly humans, a primaquine derivative of formula 1

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or a pharmaceutical composition containing said primaquine derivative of formula (1), wherein the enaminone functionality of said derivative has gametocytocidal activity and low toxicity and is used as a transmission blocker:

Dependencies are inferred from the claim text.