Cell-based detection and differentiation of disease states
AssigneeMonogen, Inc.
InventorsNorman J. Pressman, Kenneth S. Hirsch, Adrian Hirsch
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Abstract
The present invention provides a method for detecting and differentiating disease states with high sensitivity and specificity. The method allows for a determination of whether a cell-based sample contains abnormal cells and, for certain diseases, is capable of determining the histologic type of disease present. The method detects changes in the level and pattern of expression of the molecular markers in the cell-based sample. Panel selection and validation procedures are also provided.
Claims35
A panel for detecting a generic disease state or discriminating between specific disease states using cell-based diagnosis, comprising a plurality of probes each of which specifically binds to a marker associated with a generic or specific disease state, wherein the pattern of binding of the component probes of the panel to cells in a cytology specimen is diagnostic of the presence or specific nature of said disease state.
A method of forming a panel for detecting a disease state or discriminating between disease states in a patient using cell-based diagnosis, comprising:
- (a) determining the sensitivity and specificity of binding of probes each of which specifically binds to a member of a library of markers associated with a disease state;
- and
- (b) selecting a limited plurality of said probes whose pattern of binding is diagnostic for the presence or specific nature of said disease state.
Dependencies are inferred from the claim text.