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US 2003/0199590 A1Published application
Prostaglandin analogues for promotion of hair growth
OwnerGerald D Cagle, Michael V.W. Bergaminiinventors
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Abstract
Methods and compositions for the promotion of hair growth in mammals, comprising PGF2α analogues are disclosed.
Claims8
A method for promoting hair growth in a mammal, comprising the topical application to mammalian skin of an effective amount of a PGF2α analogue selected from the group consisting of:
- 90
- compounds of formula IV:
- 91
- wherein:
- R1═OR, where R═H;
- C1-C12 straight-chain or branched alkyl;
- C1-C12 straight-chain or branched acyl;
- C3-C8 cycloalkyl;
- or a cationic salt moiety;
- or R═NR4R5, where R4 and R5 are the same or different and are H;
- C1-C12 straight-chain or branched alkyl;
- C1-C12 straight-chain or branched acyl;
- or C3-C8 cycloalkyl;
- R2, R3═H, or C1-C5 straight-chain or branched alkyl;
- or R2 and R3 taken together may represent O;
- X═O, S, or CH2;
- ————represents any combination of a single bond, or a cis or trans double bond for the alpha (upper) chain;
- and a single bond or trans double bond for the omega (lower) chain;
- R9═H, C1-C10 straight-chain or branched alkyl, or C1-C10 straight-chain or branched acyl;
- R11═H, C1-C10 straight-chain or branched alkyl or C1-C10 straight-chain or branched acyl;
- Y═O;
- or H and OR15 in either configuration wherein R15═H, C1-C10 straight-chain or branched alkyl, or C1-C10 straight-chain or branched acyl;
- and
- Z═Cl or CF3.
21 more elements
Dependencies are inferred from the claim text.