Naphthalene amides as potassium channel openers

A compound of formula (1):

• 10
• or a pharmaceutically acceptable salt, amide, ester or prodrug thereof wherein,
• X is selected from OH, —O-alkyl, —SH, —S-alkyl, —NH2, —NHR6, —NR6R7;
• R1 and R2 are independently selected from hydrogen, alkyl, alkylcarbonyl, alkoxycarbonyl, alkylsulfonyl, arylcarbonyl, arylsulfonyl, haloalkylcarbonyl, haloalkylsulfonyl, heterocyclecarbonyl, heterocyclesulfonyl, (NR8R9)carbonyl, (NR8R9)sulfonyl;
• R3, R4 is selected from hydrogen, alkyl, aryl, cycloalkyl, haloalkyl, heterocycle;
• R5 is selected from hydrogen, alkenyl, alkenyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxyalkyl, alkylsulfonylalkyl, alkynyl, aryl, arylalkoxyalkyl, arylalkoxycarbonyl, arylalkoxycarbonylalkyl, arylalkyl, arylcarbonyl, arylcarbonylalkyl, arylcarbonyloxyalkyl, aryloxyalkyl, aryloxycarbonyl, aryloxycarbonylalkyl, arylalkylthioalkyl, arylsulfonylalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkoxyalkyl, cycloalkylalkyl, cycloalkylcarbonyl, cycloalkyloxyalkyl, cycloalkylalkylthioalkyl, formyl, halogen, haloalkenyl, haloalkyl, haloalkylcarbonyl, haloalkynyl, heterocycle, heterocyclealkoxyalkyl, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxyalkyl, heterocyclealkylthioalkyl, hydroxy, hydroxyalkyl, mercaptoalkyl, nitro, NR10R11, (NR10R11)carbonyl, (NR10R11)carbonylalkyl, (NR10R11)sulfonyl, (NR10R11)sulfonylalkyl;
• R6, R7, R8, R9 R10 and R11 are each independently selected from hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heterocycle, and heterocyclealkyl;
• and
• n is between 0 and 6.