Treatment of ophthalmic disorders using urea and urea derivatives

A method for treating an ophthalmological disorder, said method comprising the step of:

• A. contacting with the vitreous body of an eye of the patient a therapeutic amount of a compound selected from the group consisting of:
• urea;
• urea derivatives;
• thiourea;
• thiourea derivatives;
• guanidine;
• guanidine derivatives;
• and,
• compounds having the general formula:
• 4
• Wherein:
• R is hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, C1l-C6 alkylphenyl or hydroxyl protecting group;
• R1 and R2 are each independently hydrogen, C1-C6 alkyl, C3-C8 cycloalky, C2-C6 alkynyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkenyl, —S(O)q(C1-C6 alkenyl) or
• 5
• Wherein A is —CH2—, —O—, —S—, —S(O)— or —S(O)2—:
• W1 and W2 are each independently hydrogen, halo, hydroxyl, C1-C4 alkyl, C1-C4 alkoxy,, C1-C4 alkylthio,, C2-C4 alkenyl, or, C2-C4 alkynyl;
• R3 is hydrogen,, C1-C8 alkyl,, C3-C8 cycloalkyl, or, C1-C6 alkylphenyl;
• X is O, S, or NR4;
• R4 is hydrogen,, C1-C6 alkyl,, C1-C4 alkylphenyl or, C1-C6 alkoxy;
• R5 is hydrogen,, C3-C8 cycloalkyl or C1-C8 alkyl;
• 6
• Wherein Z1 and Z2 are each independently hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, hydroxyl, C2-C4 alkenyl, C2-C6 alkyl, C1-C6alkythio, halo, trifluoromethyl or —NR6R7;
• R6 and R7 are each independently hydrogen, C3-C8 cycloalkyl, C1-C6 alkyl, C1-C4 alkylphenyl;
• n is 1 to 6 all inclusive;
• m and p are each independently 0 to 6, both inclusive;
• q is 0, 1 or 2;
• and pharmaceutical salts thereof.