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AssigneeBionutrigen Co., Ltd.
InventorsSonghae Bok, Sangku Lee, Taesook Jeong, Euneai Kim, Surksik Moon, Myungsook Choi, Byunghwa Hyun, Chulho Lee, Yangkyu Choi, Gootaeg Oh
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The present invention relates to phenolic acid derivatives of the formula I and compositions for the preventing and the treating blood lipid level-related diseases comprising the phenolic acid derivatives. The compounds have excellent effects of reducing blood lipid level, inhibiting cholesterol metabolism-related enzymes and preventing and treating blood lipid level-related diseases. 1 wherein, R1, R2, R3, R4 and R5 are independently hydrogen, hydroxy or C1-C6 alkoxy; R6 is 2 Ra is hydrogen or acetyl; Rb is COORd or CH2ORd; Rc is hydrogen, benzyl, hydroxybenzyl, imidazolemethyl, indolemethyl, linear or branched C1-C6 alkyl, or C1-C6 alkyl substittuted with hydroxy, thiol(SH), thiomethyl(SCH3), NHRd, CNHNH2, CONH2 or COORd; and Rd is hydrogen, methyl, ethyl or benzyl.
A compound of the formula I:
A process for producing a compound of the formula I:
A composition for the prevention or the treatment of blood lipid level-related diseases comprising the compound of the formula I as an active ingredient.
A composition for inhibiting acyl CoA-cholesterol-O-acyltransferase (ACAT) activity comprising the compound of the formula I.
A composition for inhibiting HMG-CoA reductase activity comprising the compound of the formula I.
A food composition for the prevention or treatment of blood lipid level-related diseases comprising the compound of the formula I as an active ingredient.
Dependencies are inferred from the claim text.