Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators
OwnerJacqueline C. Bussolari, Xiaoli Chen +4inventors
InventorsJacqueline C. Bussolari, Xiaoli Chen, Bruce R. Conway, Keith T. Demarest, Hamishi N.M. Ross, Rafael Severino
Life of this patent
Estimating the term…
Abstract
Combination therapy comprising PPAR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed.
Claims67
A method for treating diabetes, Syndrome X, or associated symptoms or complications in a subject, said method comprising
- (a) administering to said subject a jointly effective amount of a glucose reabsorption inhibitor;
- and
- (b) administering to said subject a jointly effective amount of a PPAR modulator,
- said co-administration being in any order and the combined jointly effective amounts providing the desired therapeutic effect.
A method for inhibiting the onset of diabetes or Syndrome X, or associated symptoms or complications thereof in a subject, said method comprising
- (a) administering to said subject a jointly effective amount of a glucose reabsorption inhibitor;
- and
- (b) administering to said subject a jointly effective amount of a PPAR modulator,
- said co-administration being in any order and the combined jointly effective amounts providing the desired prophylactic effect.
A pharmaceutical composition comprising a glucose reabsorption inhibitor, a PPAR modulator, and a pharmaceutically acceptable carrier.
A process for formulating a pharmaceutical composition, comprising formulating together a glucose reabsorption inhibitor, a PPAR modulator that increases insulin sensitivity, and a pharmaceutically acceptable carrier.
A process for making a pharmaceutical composition comprising mixing one or more glucose reabsorption inhibitors in combination with a PPAR modulator for the preparation of a medicament for treating a condition selected from IDDM, NIDDM, IGT, IFG, obesity, nephropathy, neuropathy, retinopathy, atherosclerosis, polycystic ovary syndrome, hypertension, ischemia, stroke, heart disease, irritable bowel disorder, inflammation, and cataracts.
A method for inhibiting the progression of a prediabetic state in a subject to a diabetic condition, comprising
- (a) administering to said subject a jointly effective amount of a glucose reabsorption inhibitor;
- and
- (b) administering to said subject a jointly effective amount of a PPAR modulator,
- said co-administration being in any order and the combined jointly effective amounts providing the desired inhibiting effect.
The method of claim 68, wherein the glucose reabsorption inhibitor is a compound of Formula (I)
- 24
- wherein OX is a hydroxy group which may optionally be protected, Y is a lower alkyl group, and Z is a β-D-glucopyranosyl group wherein one or more hydroxy groups may optionally be protected.
Dependencies are inferred from the claim text.