Substituted cyclohexane derivatives

A compound of formula (I)

• 18
• wherein
• U is O or a lone pair,
• V is a single bond, O, S, —CH2—, —CH═CH—, —CH═CH—CH2—O—, or —C≡C—,
• W is CO, COO, CONR1, CSO, CSNR1, SO2, or SO2NR1,
• m and n independently from each other are from 0 to 7 and m+n is from 0 to 7, with the proviso that m is not 0 if V is O or S,
• A1 is hydrogen, lower-alkyl, hydroxy-lower-alkyl, or lower-alkenyl,
• A2 is cycloalkyl, cycloalkyl-lower-alkyl, lower-alkenyl, lower-alkynyl, heteroaryl, substituted heteroaryl, or lower-alkyl optionally substituted by R2, or
• A1 and A2 are bonded to each other to form a ring with the N atom to which they are attached, and —A1—A2— is lower-alkylene or lower-alkenylene, optionally substituted by R2, in which one —CH2— group of
• —A1—A2— can optionally be replaced by NR3, S, or O, or —A1—A2— is —CH═N—CH═CH— which can optionally be substituted by lower-alkyl,
• A3 and A4 independently from each other are hydrogen or lower-alkyl, or
• A3 and A4 are bonded to each other to form a ring together with the carbon atom to which they are attached and —A3—A4— is —(CH2)2-5—,
• A5, A6, A7 and A8 independently from each other are hydrogen or lower-alkyl,
• A9 is hydrogen, lower-alkyl, lower-alkenyl, or aryl-lower-alkyl,
• A10 is lower-alkyl, cycloalkyl, aryl, substituted aryl, aryl-lower-alkyl, substituted aryl-lower alkyl, heteroaryl, substituted heteroaryl, heteroaryl-lower-alkyl, or substituted heteroaryl-lower alkyl,
• p is 0 or 1,
• R2 is hydroxy, hydroxy-lower-alkyl, lower-alkoxy, lower-alkoxycarbonyl, N(R4,R5), thio-lower-alkoxy or halogen,
• R1, R3, R4 and R5 independently from each other are hydrogen or lower-alkyl, substituted aryl and substituted heteroaryl are aryl and heteroaryl, respectively, substituted by 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkynyl, dioxo-lower-alkylene (forming e.g. a benzodioxyl group), halogen, hydroxy, CN, CF3, NH2, N(H, lower-alkyl), N(lower-alkyl)2, aminocarbonyl, carboxy, NO2, lower-alkoxy, thio-lower-alkoxy, lower-alkylcarbonyl, lower-alkylcarbonyloxy, lower-alkoxycarbonyl, phenyl, and phenyloxy,
• and pharmaceutically acceptable salts thereof,
• with the proviso that the compound of formula (I) is not trans-naphthalene-1-sulfonic acid methyl-(4-methylaminomethyl-cyclohexylmethyl)-amide.