Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain
AssigneeAstraZeneca AB
InventorsWilliam Brown, Christopher Walpole, Zhongyong Wei
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AssigneeAstraZeneca AB
InventorsWilliam Brown, Christopher Walpole, Zhongyong Wei
Estimating the term…
Compounds of general formula (I), where R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, and triazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alcyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain. 1
A compound of the formula I
A compound according to any of the preceding claims, in form of its hydrochloride, dihydrochioride, sulfate, tartrate, ditrifluoroacetate or citrate salts.
A process for preparing a compound of formula I, comprising the reaction of,
A compound of the general formula II
Dependencies are inferred from the claim text.