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US 2003/0199543 A1Published application
Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase
AssigneeAventis Pharma Deutschland GmbH
InventorsPetra Stahl, Reinhard Kirsch, Sven Ruf, Volkmar Wehner, Klaus-Ulrich Weithmann
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Abstract
The invention is related to compounds of formula I 1 to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds, and to methods of prevention and treatment of disorders, the progression of which involve an enhanced activity of matrix metalloproteinase 13, by administering to a patient in need thereof, a pharmaceutically effective amount of such compounds.
Claims22
A compound of formula I
- 32
- R1 is
- —(C1-C10)-alkyl in which alkyl is linear or branched,
- —(C2-C10)-alkenyl in which alkenyl is linear or branched,
- —(C2-C10)-alkynyl in which alkynyl is linear or branched,
- —(C1-C4)-alkylphenyl,
- —(C1-C4)-alkyl-(C3-C7)-cycloalkyl,
- —(C3-C7)-cycloalkyl, or
- —CH2CF3;
- and
- R2, R3, R4 and R5 are each, independently of one another, hydrogen, or —(C1-C4)-alkyl;
- or a physiologically tolerated salt thereof.
9 more elements
Dependencies are inferred from the claim text.