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US 2003/0199542 A1Published application
Farnesyltransferase inhibitors
OwnerKeith W. Woods, Qun Li +1inventors
InventorsKeith W. Woods, Qun Li, Hing L. Sham
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Abstract
Compounds having the formula 1 are farnesyltransferase inhibitors. Also disclosed are methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds.
Claims10
A compound of formula (I)
- 16
- or a therapeutically acceptable salt thereof, wherein
- A is a 5- or 6-membered aromatic or non-aromatic ring wherein from 0-3 carbon atoms are replaced by nitrogen;
- D and E are independently selected from the group consisting of C and N;
- with the proviso that when one of D and E is N, the other is C;
- R1 is selected from the group consisting of aryl and heteroaryl;
- R2 and R3 are selected from the group consisting of hydrogen, alkenyl, alkoxy, alkyl, amido, amino, cyano, halo, haloalkoxy, haloalkyl, nitro, and oxo;
- and
- R4 is selected from the group consisting of arylalkyl and heteroarylalkyl.
6 more elements
Dependencies are inferred from the claim text.