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US 2003/0199539 A1Published application
Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsSabine Germeyer, Helmut Meissner, Gerd Morschhaeuser, Sabine Pestel, Michael P. Pieper, Gerald Pohl, Richard Reichl, Georg Speck
Life of this patent
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Abstract
Flourenecarboxylic acid esters of general formula 1 1 wherein X− and the groups A, R, R1, R2, R3, R3′, R4, and R4′ have the meanings given in the claims and in the specification, processes for the manufacture thereof and the use thereof as medicaments.
Claims21
A compound of general formula 1
- 19
- wherein:
- A is a group selected from
- 20
- X− is an anion with a single negative charge;
- R is hydrogen, hydroxy, methyl, ethyl, —CF3, —CHF2, or fluorine;
- R1 and R2, which are identical or different, are each C1-C5-alkyl which is optionally substituted by C3-C6-cycloalkyl, hydroxy, or halogen, or
- R1 and R2 together are a —C3-C5-alkylene-bridge;
- and
- R3, R4, R3′ and R4′, which are identical or different, are each hydrogen, —C1-C4-alkyl, —C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen
- or a physiologically acceptable salt thereof.
8 more elements
A compound of general formula 4
- 24
- wherein:
- A is a group selected from
- 25
- X− is an anion with a single negative charge;
- R is hydrogen, hydroxy, methyl, ethyl, —CF3, —CHF2, or fluorine;
- R1 is C1-C5-alkyl which is optionally substituted by C3-C6-cycloalkyl, hydroxy, or halogen;
- and
- R3, R4, R3′ and R4′, which are identical or different, are each hydrogen, —C1-C4-alkyl, —C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen
- or an acid addition salt thereof
7 more elements
Dependencies are inferred from the claim text.