Pharmaceutical formulation comprising an immune response modifier

A method of treating a dermal associated condition, the method comprising a step of:

• applying to skin a formulation comprising an immune response modifier (IRM) selected from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazoloquinoline amines, oxazoloquinoline amines, thiazolopyridine amines, oxazolopyridine amines, imidazonaphthyridine amines, imidazotetrahydronaphthyridine amines, and thiazolonaphthyridine amines;
• a fatty acid;
• a hydrophobic, aprotic component miscible with the fatty acid and comprising a hydrocarbyl group of 7 or more carbon atoms;
• and a hydrophilic viscosity enhancing agent selected from cellulose ethers and carbomers.

A method for delivering an immune response modifier (IRM) to a dermal surface, the method comprising the steps of:

• selecting a formulation comprising:
• (a) an immune response modifier selected from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazoloquinoline amines, oxazoloquinoline amines, thiazolopyridine amines, oxazolopyridine amines, imidazonaphthyridine amines, imidazotetrahydronaphthyridine amines, and thiazolonaphthyridine amines;
• (b) a fatty acid;
• (c) a hydrophobic, aprotic component miscible with the fatty acid and comprising a hydrocarbyl group of 7 or more carbon atoms;
• and
• (d) a hydrophilic viscosity enhancing agent selected from cellulose ethers and carbomers;
• and
• applying the selected topical formulation to the dermal surface.

A pharmaceutical formulation comprising:

• an immune response modifier (IRM) compound selected from the group consisting of imidazonaphthyridine amines, tetrahydroimidazonaphthyridine amines, and thiazolonaphthyridine amines;
• a fatty acid;
• and
• a hydrophobic, aprotic component miscible with the fatty acid and comprising a hydrocarbyl group of 7 or more carbon atoms.

A method for delivering an immune response modifier (IRM) to a dermal surface, the method comprising the steps of:

• selecting a formulation comprising:
• (a) an immune response modifier selected from imidazonaphthyridine amines, imidazotetrahydronaphthyridine amines, and thiazolonaphthyridine amines;
• (b) at fatty acid;
• (c) a hydrophobic, aprotic component miscible with the fatty acid and comprising a hydrocarbyl group of 7 or more carbon atoms;
• and
• applying the selected formulation to the dermal surface.