Polymorph of a pharmaceutical
OwnerJohn B. Cannon, Pawan Hansrani +4inventors
InventorsJohn B. Cannon, Pawan Hansrani, Russell L. Hertzler, John Lipari, Yeshwant D. Sanzgiri, Steven J. Wittenberger
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Abstract
Two new crystalline polymorphs of the compound of formula (I) 1 and methods for their use and preparation are disclosed.
Claims35
The crystalline polymorph of the compound of formula (I)
- 4
- with characteristic peaks in the powder X-ray diffraction pattern at values of two theta of 8.2°±0.1°, 8.4°±0.1°, 11.8°±0.1°, 12.9°±0.1°, 13.8°±0.1°, 15.1°±0.1°, 15.4°±0.1°, 17.0°±0.1°, 18.2°±0.1°, and 18.7°±0.1°.
The substantially pure crystalline polymorph of the compound of formula (I) with characteristic peaks in the powder X-ray diffraction pattern at values of two theta of 8.2°±0.1°, 8.4°±0.1°, 11.8°±0.1°, 12.9°±0.1°, 13.8°±0.1°, 15.1°±0.1°, 15.4°±0.1°, 17.0°±0.1°, 18.2°±0.1°, and 18.7°±0.1°.
The crystalline polymorph of the compound of formula (I) with characteristic peaks in the powder X-ray diffraction pattern at values of two theta of 6.8°±0.1°, 8.2°±0.1°, 8.4°±0.1°, 8.87°±0.1°, 10.7°±0.1°, 11.8°±0.1°, 15.0°±0.1°, 15.7°±0.1°, 16.1°±0.1°, 16.7°±0.1°, and 17.1°±0.1°.
The substantially pure crystalline polymorph of the compound of formula (I) with characteristic peaks in the powder X-ray diffraction pattern at values of two theta of 6.8°±0.1°, 8.2°±0.1°, 8.4°±0.1°, 8.87°±0.1°, 10.7°±0.1°, 11.8°±0.1°, 15.0°±0.1°, 15.7°±0.1°, 16.1°±0.1°, 16.7°±0.1°, and 17.1°±0.1°.
The process of claim 18 wherein the C4-C7 ether is methyl tert-butyl ether.
Dependencies are inferred from the claim text.