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US 2003/0199536 A1Published application
Compounds having unique CB1 receptor binding selectivity and methods for their production and use
AssigneeResearch Triangle Institute
InventorsBrian F. Thomas, Herbert H. Seltzman, Maria Elena Y. Francisco
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Abstract
Compounds are provided that are amide analogs of SR141716A having unique CB1 receptor selectivity and providing WIN sparing binding characteristics, pharmaceutical compositions containing the compounds and their use in a method of treatment of CB1 receptor related disorders, such as obesity, schizophrenia, memory dysfunction and marijuana abuse.
Claims15
A compound comprising:
- an alkyl amide of formula (II) or formula (III)
- 6
- wherein R is a linear or branched hydrocarbon group having from 7 to 12 carbons, or in the case of formula III, R can also be n-piperidinyl.
A pharmaceutical composition, comprising:
- an alkyl amide of formula (II) or formula (III)
- 7
- wherein R is a linear or branched hydrocarbon group having from 7 to 12 carbons, or in the case of Formula III, R can also be N-piperidinyl,
- and a pharmaceutically acceptable carrier.
1 more element
A method for the treatment of a CB1 receptor related disorder, comprising:
- administering to a subject in need thereof, an effective amount of an alkyl amide compound of Formula (II) or Formula (III)
- 8
- wherein R is a linear or branched hydrocarbon group having from 7 to 12 carbons, or in the case of Formula III, R can also be N-piperidinyl.
The method of claim 10, wherein R is a linear alkyl group.
Dependencies are inferred from the claim text.