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OwnerClaudio Cavazza, Claudio Pisano +1inventors
InventorsClaudio Cavazza, Claudio Pisano, Loredana Vesci
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A method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent of the family of platin compounds, taxanes, epothilone class, vinca alkaloids, said method comprising the administration in a co-ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies, an effective amount of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof. In case of prevention, acetyl L-carnitine is administered to a subject, in view of the need of a treatment with an anticancer agent, immediately before or immediately after surgical removal of the tumor, but in any case before the administration of the anticancer agent. Acetyl L-carnitine can enhance the supportive effect of physiological NGF during chemotherapy-induced neuropathy, thus avoiding the problem of the local and general side effects of the exogenous administration of NGF which are a major problem of this neuroprotective strategy.
A method for preventing and/or treating peripheral neuropathies induced by the administration of a peripheral neuropathy-inducing anticancer agent, said method comprising the administration in a co-ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies, an effective amount of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof.
A method for preventing peripheral neuropathies induced by the administration of a peripheral neuropathy-inducing anticancer agent, said method comprising the administration to a subject in view of the need of a treatment with said anticancer agent of an effective amount of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof.
A method for preventing peripheral neuropathies induced by the administration of a peripheral neuropathy-inducing anticancer agent, said method comprising the administration to a subject in view of the need of a treatment with said anticancer agent of an effective amount of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof, wherein, in said method, the administration of said acetyl L-carnitine is started immediately before or immediately after surgical removal of the tumor.
The method according to claim 17, wherein said anticancer agent is selected from the group consisting of Taxol, Cisplatin, Carboplatin, Oxaliplatin, Epothilone, Vinorelbine and Vincristine.
A composition which in combination comprises:
A kit comprising
Dependencies are inferred from the claim text.