Novel amino carboxy alkyl derivatives of barbituric acid
OwnerKenneth Curryinventor
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Abstract
The present invention relates to therapeutically active novel amino, carboxy, alkyl derivatives of barbituric acid of Formula (I), wherein at least one of R1, R2, R3 or R4 comprises an NH2 moiety and at least one of R1, R2, R3 or R4 comprises one COOH moiety. Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.
Claims6
(Amended) A [pharmaceutical] composition, comprising a pharmaceutically acceptable carrier, diluent or excipient and a compound formula (I):
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- or stereoisomers thereof or pharmaceutically acceptable salts or hydrates thereof, wherein:
- R1 and R2 can be the same or different and selected from the group comprising H, NH2, COOH and (CH2)nCR5WY, wherein:
- n=0-5, W is H or COOH, Y is H or NH2, R5 is H, alkyl, aryl, or (CH2)mR6, wherein:
- m=0-5 and R6 is H, carboxyl, phosphono, phosphino, sulfono, sulfino, borono, tetrazol, or isoxazol;
- R3 and R4 can be the same or different and selected from the group comprising H, alkyl, aryl, acyl, CH2COOH, NH2 and —(CH2)n′CHCO2H NH2, wherein:
- n′ is 0-5;
- and X is O or S;
- with the proviso, that at least one of R1, R2, R3 or R4 comprises an NH2 moiety and at least one of R1, R2, R3 or R4 comprises one COOH moiety.
Dependencies are inferred from the claim text.