New compounds derived from quinazoline

1- A compound selected from those of formula (I):

• 15
• wherein:
• A represents a bond, alkylene, alkenylene, alkynylene, T, *-A1-T-, *-T-A1-, *-A1-T-A′1- or *-A-T-A′1-T′- (wherein T and T′, which may be identical or different, each represents carbonyl, carbonyloxy, thio, sulphinyl, sulphonyl, oxy, amino, aminoalkyl, aminoaryl, carbonylamino, carbonylaminoalkyl, carbonylaminoaryl, oxycarbonyl, aminocarbonyl, aminoalkylcarbonyl, aminoarylcarbonyl, sulphonylamino, sulphonylaminoalkyl, sulphonylaminoaryl, aminosulphonyl, aminoalkylsulphonyl or aminoarylsulphonyl;
• A1 and A′1, which may be identical or different, each represents alkylene, alkenylene or alkynylene;
• and the symbol “*” represents the point of attachment to the nitrogen atom N3 of the quinazoline ring),
• B represents an optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted arylaminoaryl or optionally substituted arylalkylaryl,
• D represents alkylene in which a carbon atom of the hydrocarbon chain may be substituted by an optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl,
• X represents oxygen or sulphur,
• R1 represents halogen, alkyl, alkoxy, hydroxy, mercapto, cyano, amino, alkylamino, dialkylamino, nitro, perhaloalkyl, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, carbamoyl or alkoxycarbonylamino,
• R2 represents hydrogen, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, it being possible for each of those groups to be optionally substituted by a substituent selected from halogen, alkyl, alkoxy, hydroxy, mercapto, cyano, amino, alkylamino, dialkylamino, nitro, perhaloalkyl, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, carbamoyl, alkoxycarbonylamino, optionally substituted arylamino or optionally substituted arylalkyl,
• m represents an integer of from 0 to 4 inclusive,
• n represents an integer of from 0 to 3 inclusive,
• its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base,
• wherein:
• where m is greater than 1, R1 may be identical to or different from one another,
• where n is greater than 1, R2 may be identical to or different from one another,
• when the two nitrogen atoms of the imidazolyl group are substituted, the imidazolyl group becomes a cationic imidazolinium group,
• the term “alkyl” denotes linear or branched hydrocarbon chain containing from 1 to 6 carbon,
• the term “alkoxy” denotes linear or branched alkyl-oxy group containing from 1 to 6 carbon,
• the term “alkylene” denotes linear or branched divalent hydrocarbon chain containing from 1 to 6 carbon,
• the term “alkenylene” denotes linear or branched divalent hydrocarbon chain containing from 1 to 3 double bonds and from 2 to 6 carbon,
• the term “alkynylene” denotes linear or branched divalent hydrocarbon chain containing from 1 to 3 triple bonds and from 2 to 6 carbon,
• the term “cycloalkyl” denotes saturated or partially saturated mono- or poly-cyclic group containing from 3 to 10 carbon,
• the term “heterocycloalkyl” denotes saturated or partially unsaturated mono- or poly-cyclic group of from 5 to 7 ring members containing from 1 to 3 hetero atoms selected from nitrogen, oxygen and sulphur,
• the term “aryl” denotes phenyl, naphthyl or biphenyl,
• the term “heteroaryl” denotes mono- or bi-cyclic group that is aromatic or contains at least one aromatic ring and that has from 5 to 11 ring members and contains from 1 to 3 hetero atoms selected from nitrogen, oxygen and sulphur,
• the expression “optionally substituted” governing the term alkyl denotes that from one to three carbon of the hydrocarbon chain may be substituted by one to three identical or different substituents selected from halogen, alkyl, alkoxy, hydroxy, mercapto, cyano, amino, alkylamino, dialkylamino, nitro, perhaloalkyl, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, carbamoyl or alkoxycarbonylamino,
• the expression “optionally substituted” governing the terms aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkylaryl and arylaminoaryl denotes, unless specified to the contrary, that the cyclic moiety or moieties of those groups may be substituted by from one to three identical or different substituent selected from halogen, alkyl, alkoxy, hydroxy, mercapto, cyano, amino, alkylamino, dialkylamino, nitro, perhaloalkyl, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, carbamoyl or alkoxycarbonylamino,
• the term “perhaloalkyl” denotes methyl, ethyl, propyl or butyl substituted by from 1 to 9 halogen atoms.