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US 2003/0199523 A1Published application
Heterocyclic calcium in channel blockers
OwnerTerrance P. Snutchinventor
Life of this patent
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Abstract
Compounds comprising at least one aromatic ring linked to a heterocycle are described which are useful in altering abnormal calcium channel activity.
Claims7
A method to treat conditions associated with abnormal calcium ion channel activity which method comprises administering to a subject in need of such treatment an effective amount of a compound of the formula
- Ar—linker—Het (1)
- or Ar2CH—linker—Het (2)
- or the salts thereof,
- wherein each Ar is independently a 6-membered optionally substituted aromatic ring containing one or more heteroatoms selected from the group consisting of S, O and N, which ring is optionally coupled through —O— to the linker;
- the linker is an alkylene type chain of 2-10 sequentially connected atoms selected from the group consisting of C, N, O, and S which connecting atoms are optionally substituted;
- and
- each Het is a 5-membered optionally substituted heterocyclic ring which contains at least one N or S atom:
4 more elements
A pharmaceutical composition for use in treating conditions characterized by abnormal calcium channel activity which composition comprises, in admixture with a pharmaceutically acceptable excipient, a dosage amount of at least one compound of formula (1) or (2) or the salts thereof.
Dependencies are inferred from the claim text.