Kinase inhibitors

A compound of formula (II)

• 103
• or a therapeutically acceptable salt thereof, wherein
• L1 is selected from the group consisting of a bond, —O—, —N(R5)—, alkenyl, alkynyl, —N(R5)C(O)—, and —C(O)N(R5)—;
• L2 is selected from the group consisting of a bond, —O—, —N(R5)—, —N(R5)C(O)—, and —C(O)N(R5)—;
• L3 is selected from the group consisting of a bond, alkylidene, and alkylene, wherein the alkylidene and the alkylene are optionally substituted with one or two substituents independently selected from the group consisting of amino, cyano, and hydroxy;
• R1 is selected from the group consisting of aryl, heteroaryl, and heterocycle;
• R2 and R4 are independently selected from the group consisting of hydrogen, alkenyl, alkynyl, arylalkynyl, amino, cyano, cyanoalkenyl, halo, hydroxyalkyl, and heteroaryl;
• wherein the heteroaryl is selected from the group consisting of furyl, pyrazinyl, thiazolyl, and thienyl;
• or
• R2 and L1, together with the carbon atoms to which they are attached, form a ring selected from the group consisting of dihydropyrrolyl, pyrazolyl, and phenyl;
• or
• R4 and L2, together with the carbon atoms to which they are attached, form a ring selected from the group consisting of dihydropyrrolyl, phenyl, pyridinyl, and pyrrolyl;
• wherein the ring can be optionally substituted with oxo;
• provided that when L3 is alkylidene, R4 and L2, together with the carbon atoms to which they are attached, form a ring selected from the group consisting of dihydropyrrolyl, phenyl, pyridinyl, and pyrrolyl;
• wherein the ring can be optionally substituted with oxo;
• R3 is absent or selected from the group consisting of hydrogen, aryl, arylalkoxy, arylalkylthio, aryloxy, arylthio, cycloalkyl, heteroaryl, heteroarylalkoxy, heteroaryloxy, and heterocycle;
• R6 are independently selected from the group consisting of hydrogen, aryl, arylalkoxy, arylalkylthio, aryloxy, arylthio, cycloalkyl, heteroaryl, and heteroarylalkoxy, heteroaryloxy, and heterocycle;
• provided that when L1 and L2 are bonds, at least one of R3 and R6 is other than hydrogen;
• R5 is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, arylcarbonyl, arylsulfonyl, and heteroarylsulfonyl;
• and
• X is selected from the group consisting of C(R8) and N;
• wherein R8 is selected from the group consisting of hydrogen, amino, carboxy, cyano, and halo.

A compound of formula (III)

• 104
• or a therapeutically acceptable salt thereof, wherein
• L1 is selected from the group consisting of a bond, —O—, —N(R5)—, alkenyl, alkynyl, and —N(R5)C(O)—;
• L2 is selected from the group consisting of a bond, —O—, —N(R5)—, —N(R5)C(O)—, and —C(O)N(R5)—;
• L3 is alkylene, wherein the alkylene is substituted with one or two substituents independently selected from the group consisting of amino and hydroxy;
• R1 is selected from the group consisting of aryl, heteroaryl, and heterocycle;
• R2 and R4 are independently selected from the group consisting of hydrogen and halo;
• R3 and R6 are independently selected from the group consisting of hydrogen, aryl, arylalkoxy, and heteroaryl;
• provided that when L1 and L2 are bonds, at least one of R3 and R6 is other than hydrogen;
• and
• R5 is selected from the group consisting of hydrogen and alkyl.