Novel anti-inflammatory androstane derivative
AssigneeGlaxo Group Limited
InventorsKeith Biggadike, Steven John Coote, Rosalyn Kay Nice
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Abstract
According to one aspect of the invention, there is provided a compound of formula (I) 1 and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.
Claims63
A compound of formula (I)
- 26
- and solvates thereof:
A compound of formula (II)
- 28
- or a salt thereof.
A compound of formula (IIA)
- 30
A compound of formula (VI)
- 31
A compound of formula (VII)
- 32
- or a salt thereof.
A compound of formula (VIII)
- 33
A compound of formula (IX)
- 34
A compound of formula (IXA)
- 35
- wherein X represents halogen.
A compound of formula (XII)
- 36
- or a salt thereof.
A compound of formula (XV)
- 37
- wherein P represents a hydroxy protecting group.
A compound of formula (XVI)
- 38
A compound of formula (XVII)
- 39
- or a salt thereof wherein P represents a hydroxy protecting group.
A compound of formula (XX)
- 40
- or a salt thereof or a derivative wherein the 11-carbonyl group is masked.
A compound of formula (XXIII)
- 41
- wherein L represents a leaving group other than fluorine.
A compound of formula (XIII)
- 46
A compound of formula (XIV)
- 47
- or a salt thereof,
A compound of formula (XXI)
- 48
- or a derivative wherein the 11-carbonyl group is masked
A compound of formula (XXII)
- 49
- or a derivative wherein the 11-carbonyl group is masked
A compound of formula (X)
- 50
Dependencies are inferred from the claim text.