Therapeutic combinations for cardiovascular and inflammatory indications
AssigneePharmacia Corporation
InventorsKaren Seibert, Bradley T. Keller, Peter C.. Isakson
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Abstract
The present invention provides therapeutic combinations and methods for treating or preventing a hypercholesterolemia-related or an inflammation-related condition in a subject in need of such treatment or prevention. One therapeutic combination comprises an ASBT inhibitor combined with COX-2 inhibitor. A further therapeutic combination comprises an ASBT inhibitor, a COX-2 inhibitor and an HMG Co-A reductase inhibitor. Another therapeutic combination comprises a chromene COX-2 inhibitor and an HMG Co-A reductase inhibitor.
Claims20
A method for treating or preventing a hypercholesterolemia-related or an inflammation-related condition in a subject in need of such treatment or prevention, comprising treating the subject with an amount of an apical sodium co-dependent bile acid transport inhibitor, an amount of a cyclooxygenase-2 selective inhibitor or prodrug, wherein the amount of the apical sodium co-dependent bile acid transport inhibitor, the amount of the cyclooxygenase-2 selective inhibitor together constitute a hypercholesterolemia-related condition effective amount or an inflammation-related condition effective amount of the apical sodium co-dependent bile acid transport inhibitor and the cyclooxygenase-2 inhibitor.
A pharmaceutical combination comprising an amount of an apical sodium co-dependent bile acid transport inhibitor, an amount of a cyclooxygenase-2 selective inhibitor or prodrug, and a pharmaceutically acceptable carrier, wherein the amount of the apical sodium co-dependent bile acid transport inhibitor and the amount of the cyclooxygenase-2 selective inhibitor together constitute a hypercholesterolemia-related condition effective amount or an inflammation-related condition effective amount of the apical sodium co-dependent bile acid transport inhibitor and the cyclooxygenase-2 selective inhibitor.
A kit comprised of an amount of an apical sodium co-dependent bile acid transport inhibitor in a dosage formulation and an amount of a cyclooxygenase-2 selective inhibitor or prodrug in a separate dosage formulation wherein the amount of the apical sodium co-dependent bile acid transport inhibitor and the amount of the cyclooxygenase-2 selective inhibitor together constitute a hypercholesterolemia-related condition effective amount or an inflammation-related condition effective amount of the apical sodium co-dependent bile acid transport inhibitor and the cyclooxygenase-2 selecti e inhibitor.
Dependencies are inferred from the claim text.