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OwnerLi-Wei Hsu, Su-Chen Changinventors
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The invention discloses a compound of the general formula (I) 1 wherein X is selected from the group consisting of —(CH2)nOH, —(CH2)nNH2, —(CH2)nSH, —(CH2)mCOOH, —(CH2)mCOOR, —(CH2)mCONH2, —(CH2)m″CONH—OH, (CH2)m″CONH—R, and —(CH2)n′O(PO3)m″(m″+1), wherein n=2, 3, 4 or 5; n′=2 or 3; m=1, 2, 3 or 4; m′=1, 2, 3, 4, 5 or 6; m″=1, 2 or 3; and R=—Cm′H2m′+1, or an aryl group, especially 1-[3,4-dihydroxy-5-(2-hydroxyethyl)-tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione, methods for treating or preventing MMP-related disorders and TNFα-related disorders alone or simultaneously, methods for the inhibition of the invasion and/or metastasis of ovarian carcinoma, and pharmaceutical compositions containing said compound for said treatments.
A method for inhibiting the invasion and/or metastasis of a carcinoma in a mammal in need thereof, comprising administering to said mammal an effective amount of a compound of formula I
A pharmaceutical composition for inhibiting the invasion and/or metastasis of a carcinoma in a mammal in need thereof, which comprises an effective amount of the compound of formula I
Dependencies are inferred from the claim text.