Substituted diamino-1,3,5-triazine derivatives

An antiretroviral combination, comprising:

• a compound of formula (I)
• 35
• a pharmaceutically acceptable acid addition salt thereof or a stereochemically isomeric form thereof, wherein
• R1 and R2 are each independently selected from hydrogen;
• hydroxy;
• amino;
• C1-6alkyl;
• C1-6alkyloxy;
• C1-6alkylcarbonyl;
• C1-6alkyloxycarbonyl;
• Ar1;
• mono- or di(C1-6alkyl)amino;
• mono- or di(C1-6alkyl)aminocarbonyl;
• dihydro-2(3H)-furanone;
• C1-6alkyl substituted with one or two substituents each independently selected from amino, imino, aminocarbonyl, aminocarbonylamino, hydroxy, hydroxyC1-6alkyloxy, carboxyl, mono- or di(C1-6alkyl)amino, C1-6alkyloxycarbonyl and thienyl;
• or
• R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)aminoC1-4alkylidene;
• R3 is hydrogen, Ar1, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl;
• and
• R4, R5, R7 and R8 are each independently selected from hydrogen, hydroxy, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy;
• R6 is cyano or aminocarbonyl;
• L is C1-10alkyl;
• C3-10alkenyl;
• C3-10alkynyl;
• C3-7cycloalkyl;
• or
• L is C1-10alkyl substituted with one or two substituents independently selected from C3-7cycloalkyl;
• indolyl or indolyl substituted with one, two, three or four substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy, C1-6alkylcarbonyl;
• phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, hydroxy, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy, C1-6alkylcarbonyl;
• and,
• Ar1 is phenyl, or phenyl substituted with one, two or three substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, cyano, nitro or trifluoromethyl;
• and
• an antiretroviral compound different from said compound of formula (I).