Chimeric immunomodulatory compounds and methods of using the same - ll

A chimeric immunomodulatory compound (CIC) comprising at least three nucleic acid moieties and at least one nonnucleic acid spacer moiety,

• wherein at least one nucleic acid moiety comprises the sequence 5′-CG-3′ and said spacer moiety comprises HEG, TEG, propyl, butyl, hexyl, pentaerythritol, 2-(hydroxymethyl)ethyl, glycerol, a polysaccharide, 1,3-diamino-2-propanol, or a dendrimer;
• and wherein said CIC has at least one immunomodulatory activity selected from the group consisting of (i) the ability to stimulate IFN-γ production from human perpheral blood mononuclear cells and (ii) the ability to stimulate INF-α production from human perpheral blood mononuclear cells.