Regeneration of endogenous myocardial tissue by induction of neovascularization
OwnerSilviu Itescuinventor
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Abstract
This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject an amount of an agent effective to cause cardiomyocyte proliferation within the subject's heart so as to thereby treat the disorder. This invention further provides the instant method wherein the agent is human endothelial progenitor cells. This invention also provides methods of determining the susceptibility of a cardiomyocyte in a subject to apoptosis.
Claims49
A method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject an amount of an agent effective to cause cardiomyocyte proliferation within the subject's heart so as to thereby treat the disorder.
A method of determining the susceptibility of a cardiomyocyte in a subject to apoptosis comprising:
- (a) quantitating the amount of mRNA encoding peroxiredoxin in the cardiomyocyte;
- (b) quantitating the amount of mRNA encoding Vitamin D3 Up-Regulated Protein-1 in the cardiomyocyte;
- and
- (c) determining the ratio of the amount of mRNA encoding peroxiredoxin:
- amount of mRNA encoding Vitamin D3 Up-Regulated Protein-1, wherein a low ratio indicates a high susceptibility of the cardiomyocyte to apoptosis and a high ratio indicates a low susceptibility of the cardiomyocyte to apoptosis in the subject.
A method of determining the susceptibility of a cardiomyocyte in a subject to apoptosis comprising:
- (a) quantitating the expression of a peroxiredoxin protein in the cardiomyocyte;
- (b) quantitating the expression of Vitamin D3 Up-Regulated Protein-1 in the cardiomyocyte;
- and
- (c) determining the ratio of the peroxiredoxin protein expression:
- Vitamin D3 Up-Regulated Protein-1 expression, wherein a low ratio indicates a high susceptibility of the cardiomyocyte to apoptosis and a high ratio indicates a low susceptibility of the cardiomyocyte to apoptosis in the subject.
Dependencies are inferred from the claim text.