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US 2003/0199461 A1Published application
3-beta-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof
AssigneeAnadys Pharmaceuticals, Inc.
InventorsDevron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden
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Abstract
The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
Claims11
A compound represented by Formula I:
- 25
- wherein:
- R1 is independently H, —C(O)R3, or a racemic, L-, or D-amino acid group —C(O)CHNH2R4, wherein R3 is a substituted or unsubstituted alkyl, and R4 is H, or a substituted or unsubstituted alkyl;
- R2 is H, OR5, or N(R6)2, wherein R5 is independently H or alkyl, and wherein R6 is independently H, substituted or unsubstituted alkyl, cycloalkyl, or together with nitrogen forms a substituted or unsubstituted heterocycloalkyl ring;
- and
- wherein if R2 is —OH, at least one of the R1 groups is a racemic, L-, or D-amino acid group —C(O)CHNH2R4;
- or a pharmaceutically acceptable salt.
4 more elements
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound represented by Formula I:
- 30
- wherein:
- R1 is independently H, —C(O)R3, or a racemic, L-, or D-amino acid group —C(O)CHNH2R4, wherein R3 is a substituted or unsubstituted alkyl, and R4 is H, or a substituted or unsubstituted alkyl;
- R2 is H, OR5, or N(R6)2, wherein R5 is independently H or alkyl, and wherein R6 is independently H, substituted or unsubstituted alkyl, cycloalkyl, or together with nitrogen forms a substituted or unsubstituted heterocycloalkyl ring;
- and
- wherein if R2 is —OH, at least one of the R1 groups is a racemic, L-, or D-amino acid group —C(O)CHNH2R4;
- or a pharmaceutically acceptable salt.
4 more elements
Dependencies are inferred from the claim text.